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Lamb2 laminin, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 16779, updated on 10-Jan-2023

Summary

Official Symbol
Lamb2provided by MGI
Official Full Name
laminin, beta 2provided by MGI
Primary source
MGI:MGI:99916
See related
Ensembl:ENSMUSG00000052911 AllianceGenome:MGI:99916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lams; npht; Lamb-2
Summary
Enables integrin binding activity. Acts upstream of or within several processes, including metanephric glomerulus development; neurogenesis; and visual perception. Located in basement membrane and neuromuscular junction. Part of laminin-3 complex. Is active in synaptic cleft. Is expressed in several structures, including Reichert's membrane; alimentary system; brain; decidua; and liver. Used to study Pierson syndrome and nephrosis. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 79.6), heart adult (RPKM 69.8) and 24 other tissues See more
Orthologs
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Genomic context

See Lamb2 in Genome Data Viewer
Location:
9 F2; 9 59.4 cM
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108357046..108367729)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108479847..108490530)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC048562 Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene glutaminyl-tRNA synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within astrocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon extension involved in regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis involved in differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metanephric glomerular basement membrane development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephric podocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of basement membrane organization NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual perception IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
part_of laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of laminin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of laminin-3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of laminin-3 complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein complex involved in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
laminin subunit beta-2
Names
Laminin S
S-LAM beta
S-laminin subunit beta
laminin-11 subunit beta
laminin-14 subunit beta
laminin-15 subunit beta
laminin-3 subunit beta
laminin-4 subunit beta
laminin-7 subunit beta
laminin-9 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411228.1NP_001398157.1  laminin subunit beta-2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT010508
    UniProtKB/Swiss-Prot
    Q8R0Y0
  2. NM_001411229.1NP_001398158.1  laminin subunit beta-2 precursor

    Status: VALIDATED

    Source sequence(s)
    CT010508
    UniProtKB/Swiss-Prot
    Q8R0Y0
  3. NM_008483.4NP_032509.2  laminin subunit beta-2 precursor

    See identical proteins and their annotated locations for NP_032509.2

    Status: VALIDATED

    Source sequence(s)
    CT010508
    Consensus CDS
    CCDS23528.1
    UniProtKB/Swiss-Prot
    Q61292, Q8R0Y0
    UniProtKB/TrEMBL
    Q3USI2
    Related
    ENSMUSP00000069087.5, ENSMUST00000065014.10
    Conserved Domains (4) summary
    COG1196
    Location:12571789
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00055
    Location:524565
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:784832
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:64284
    Laminin_N; Laminin N-terminal (Domain VI)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108357046..108367729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511648.3XP_006511711.1  laminin subunit beta-2 isoform X1

    UniProtKB/Swiss-Prot
    Q61292
    Conserved Domains (4) summary
    COG1196
    Location:12571789
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00055
    Location:524565
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:784832
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:64284
    Laminin_N; Laminin N-terminal (Domain VI)