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Lama4 laminin, alpha 4 [ Mus musculus (house mouse) ]

Gene ID: 16775, updated on 1-Mar-2024

Summary

Official Symbol
Lama4provided by MGI
Official Full Name
laminin, alpha 4provided by MGI
Primary source
MGI:MGI:109321
See related
Ensembl:ENSMUSG00000019846 AllianceGenome:MGI:109321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within blood vessel development and brown fat cell differentiation. Located in basement membrane and neuromuscular junction. Is active in synaptic cleft. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 25.5), subcutaneous fat pad adult (RPKM 21.8) and 19 other tissues See more
Orthologs
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Genomic context

See Lama4 in Genome Data Viewer
Location:
10 B1; 10 20.02 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (38841511..38986184)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (38965515..39110188)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26375 Neighboring gene ret finger protein-like 4B Neighboring gene STARR-seq mESC enhancer starr_26376 Neighboring gene STARR-seq mESC enhancer starr_26377 Neighboring gene predicted gene, 17779 Neighboring gene STARR-seq mESC enhancer starr_26378 Neighboring gene STARR-seq mESC enhancer starr_26379 Neighboring gene STARR-seq mESC enhancer starr_26383 Neighboring gene family with sequence similarity 229, member B Neighboring gene STARR-seq mESC enhancer starr_26384 Neighboring gene tubulin, epsilon 1 Neighboring gene cellular communication network factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC141567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
laminin subunit alpha-4
Names
laminin [a]4
laminin-14 subunit alpha
laminin-8 subunit alpha
laminin-9 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010681.4NP_034811.2  laminin subunit alpha-4 precursor

    See identical proteins and their annotated locations for NP_034811.2

    Status: VALIDATED

    Source sequence(s)
    AC118224, AC153958, BC115942
    Consensus CDS
    CCDS35882.1
    UniProtKB/Swiss-Prot
    O88785, P70409, P97927, Q14BF2
    Related
    ENSMUSP00000019992.6, ENSMUST00000019992.6
    Conserved Domains (6) summary
    smart00282
    Location:8531008
    LamG; Laminin G domain
    cd00055
    Location:187238
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14821617
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:289547
    Laminin_I; Laminin Domain I
    pfam06009
    Location:727854
    Laminin_II; Laminin Domain II
    cl21509
    Location:610787
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    38841511..38986184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)