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Lama3 laminin, alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 16774, updated on 22-May-2018
Official Symbol
Lama3provided by MGI
Official Full Name
laminin, alpha 3provided by MGI
Primary source
MGI:MGI:99909
See related
Ensembl:ENSMUSG00000024421 Vega:OTTMUSG00000045059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
[a]3B; Lama3B
Expression
Broad expression in lung adult (RPKM 9.8), colon adult (RPKM 3.3) and 15 other tissues See more
Orthologs
See Lama3 in Genome Data Viewer
Location:
18 A1; 18 6.2 cM
Exon count:
78
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (12333718..12583013)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (12492533..12741522)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene regulator of MON1-CCZ1 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene ecotropic viral integration site 5 pseudogene Neighboring gene predicted gene, 36232 Neighboring gene predicted gene, 41668 Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene microRNA 1948

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
hemidesmosome assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
hemidesmosome ISO
Inferred from Sequence Orthology
more info
 
laminin-3 complex ISO
Inferred from Sequence Orthology
more info
 
laminin-5 complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
laminin subunit alpha-3
Names
epiligrin subunit alpha
kalinin subunit alpha
laminin-5 subunit alpha
laminin-6 subunit alpha
laminin-7 subunit alpha
nicein subunit alpha
nicein, 150kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347461.1NP_001334390.1  laminin subunit alpha-3 isoform 3A precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (3A) with a distinct N-terminus, compared to isoform 3B.
    Source sequence(s)
    AC102131, AC139027
    Consensus CDS
    CCDS84360.1
    UniProtKB/Swiss-Prot
    Q61789
  2. NM_010680.1NP_034810.1  laminin subunit alpha-3 isoform 3B precursor

    See identical proteins and their annotated locations for NP_034810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (3B).
    Source sequence(s)
    AC102131, AC102248, AC139027, AC157909
    Consensus CDS
    CCDS50222.1
    UniProtKB/Swiss-Prot
    Q61789
    Related
    ENSMUSP00000089703.6, OTTMUSP00000066092, ENSMUST00000092070.12, OTTMUST00000118410
    Conserved Domains (10) summary
    smart00136
    Location:40294
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:15091638
    LamB; Laminin B domain
    smart00282
    Location:24312566
    LamG; Laminin G domain
    cd00055
    Location:14011451
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:31553306
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:12631311
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:18422101
    Laminin_I; Laminin Domain I
    pfam06009
    Location:22842412
    Laminin_II; Laminin Domain II
    pfam17045
    Location:19682248
    CEP63; Centrosomal protein of 63 kDa
    cl21509
    Location:20902204
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    12333718..12583013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525691.3XP_006525754.1  laminin subunit alpha-3 isoform X7

    Conserved Domains (4) summary
    smart00136
    Location:40294
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:15091638
    LamB; Laminin B domain
    cd00055
    Location:14011451
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00053
    Location:12631311
    Laminin_EGF; Laminin EGF domain
  2. XM_006525686.3XP_006525749.1  laminin subunit alpha-3 isoform X2

    Conserved Domains (9) summary
    smart00136
    Location:40294
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:15091638
    LamB; Laminin B domain
    smart00282
    Location:24322567
    LamG; Laminin G domain
    cd00055
    Location:14011451
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:25992739
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:12631311
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:18422101
    Laminin_I; Laminin Domain I
    pfam06009
    Location:22852413
    Laminin_II; Laminin Domain II
    cl21509
    Location:21462253
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. XM_006525685.3XP_006525748.1  laminin subunit alpha-3 isoform X1

    Conserved Domains (9) summary
    smart00136
    Location:40294
    LamNT; Laminin N-terminal domain (domain VI)
    smart00281
    Location:15091638
    LamB; Laminin B domain
    smart00282
    Location:24322567
    LamG; Laminin G domain
    cd00055
    Location:14011451
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:31563307
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:12631311
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:18422101
    Laminin_I; Laminin Domain I
    pfam06009
    Location:22852413
    Laminin_II; Laminin Domain II
    cl21509
    Location:21462253
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. XM_006525687.3XP_006525750.1  laminin subunit alpha-3 isoform X3

    Conserved Domains (8) summary
    smart00281
    Location:348477
    LamB; Laminin B domain
    smart00282
    Location:12711406
    LamG; Laminin G domain
    cd00055
    Location:240290
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:19952146
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:102150
    Laminin_EGF; Laminin EGF domain
    pfam06008
    Location:681940
    Laminin_I; Laminin Domain I
    pfam06009
    Location:11241252
    Laminin_II; Laminin Domain II
    cl21509
    Location:9851092
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. XM_017317841.1XP_017173330.1  laminin subunit alpha-3 isoform X4

    Conserved Domains (9) summary
    smart00281
    Location:35164
    LamB; Laminin B domain
    smart00282
    Location:9581093
    LamG; Laminin G domain
    cd00055
    Location:209255
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:16821833
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:292330
    TNFRSF; CRD2 [structural motif]
    pfam06008
    Location:368627
    Laminin_I; Laminin Domain I
    pfam06009
    Location:811939
    Laminin_II; Laminin Domain II
    cl21509
    Location:672779
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl22855
    Location:277345
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  6. XM_006525689.3XP_006525752.1  laminin subunit alpha-3 isoform X5

    Conserved Domains (7) summary
    smart00282
    Location:826961
    LamG; Laminin G domain
    cd00055
    Location:77123
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15501701
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:148217
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    pfam06008
    Location:236495
    Laminin_I; Laminin Domain I
    pfam06009
    Location:679807
    Laminin_II; Laminin Domain II
    cl21509
    Location:540647
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. XM_006525690.2XP_006525753.1  laminin subunit alpha-3 isoform X6

    Related
    ENSMUSP00000140104.1, OTTMUSP00000066093, ENSMUST00000188815.1, OTTMUST00000118411
    Conserved Domains (7) summary
    smart00282
    Location:825960
    LamG; Laminin G domain
    cd00055
    Location:77123
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:15491700
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00185
    Location:148217
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    pfam06008
    Location:236495
    Laminin_I; Laminin Domain I
    pfam06009
    Location:678806
    Laminin_II; Laminin Domain II
    cl21509
    Location:540646
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

  1. XR_385977.3 RNA Sequence

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