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ZNF366 zinc finger protein 366 [ Homo sapiens (human) ]

Gene ID: 167465, updated on 10-Dec-2024

Summary

Official Symbol
ZNF366provided by HGNC
Official Full Name
zinc finger protein 366provided by HGNC
Primary source
HGNC:HGNC:18316
See related
Ensembl:ENSG00000178175 MIM:610159; AllianceGenome:HGNC:18316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCSCRIPT; DC-SCRIPT
Summary
Enables nuclear estrogen receptor binding activity and transcription corepressor activity. Involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in placenta (RPKM 4.6), fat (RPKM 4.5) and 21 other tissues See more
Orthologs
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Genomic context

See ZNF366 in Genome Data Viewer
Location:
5q13.2; 5q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (72439903..72507410, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (72921070..72988558, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71735730..71803237, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16080 Neighboring gene ribosomal protein L10a pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16081 Neighboring gene Y-box binding protein 1 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22651 Neighboring gene Sharpr-MPRA regulatory region 3669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16082 Neighboring gene uncharacterized LOC102503427 Neighboring gene TNPO1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:71930309-71930809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72004631-72005132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72005133-72005632 Neighboring gene ribosomal protein L7 pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MRPS27

Clone Names

  • FLJ33375, FLJ39796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 366
Names
dendritic cell-specific transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152625.3NP_689838.1  zinc finger protein 366

    See identical proteins and their annotated locations for NP_689838.1

    Status: VALIDATED

    Source sequence(s)
    AC093278, AK097115, BK000210
    Consensus CDS
    CCDS4015.1
    UniProtKB/Swiss-Prot
    Q5HYI9, Q7RTV4, Q8N895
    UniProtKB/TrEMBL
    Q0VAH5
    Related
    ENSP00000313158.5, ENST00000318442.6
    Conserved Domains (2) summary
    COG5048
    Location:253549
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255275
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    72439903..72507410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    72921070..72988558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)