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LIX1 limb and CNS expressed 1 [ Homo sapiens (human) ]

Gene ID: 167410, updated on 17-Jun-2024

Summary

Official Symbol
LIX1provided by HGNC
Official Full Name
limb and CNS expressed 1provided by HGNC
Primary source
HGNC:HGNC:18581
See related
Ensembl:ENSG00000145721 MIM:610466; AllianceGenome:HGNC:18581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Lft; C5orf11
Summary
Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 14.2), thyroid (RPKM 2.1) and 1 other tissue See more
Orthologs
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Genomic context

See LIX1 in Genome Data Viewer
Location:
5q15
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (97091867..97142611, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (97592630..97643374, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (96427571..96478315, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22829 Neighboring gene Sharpr-MPRA regulatory region 4368 Neighboring gene ribosomal protein S20 pseudogene 16 Neighboring gene leucyl and cystinyl aminopeptidase Neighboring gene MPRA-validated peak5362 silencer Neighboring gene Sharpr-MPRA regulatory region 9279 Neighboring gene SET pseudogene 22 Neighboring gene LIX1 and RIOK2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:96459480-96460679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16202 Neighboring gene RNA, U1 small nuclear 73, pseudogene Neighboring gene RIO kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22833 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:96669582-96669797 Neighboring gene YTH domain family member 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein limb expression 1 homolog
Names
Lix1 homolog
Lowfat homolog
limb expression 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153234.5NP_694966.3  protein limb expression 1 homolog

    See identical proteins and their annotated locations for NP_694966.3

    Status: VALIDATED

    Source sequence(s)
    AC008865, AK098400, BC036467
    Consensus CDS
    CCDS4088.1
    UniProtKB/Swiss-Prot
    A8K4R9, Q8N485, Q8N7I2
    Related
    ENSP00000274382.4, ENST00000274382.9
    Conserved Domains (1) summary
    pfam14954
    Location:17258
    LIX1; Limb expression 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    97091867..97142611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    97592630..97643374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)