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DCP2 decapping mRNA 2 [ Homo sapiens (human) ]

Gene ID: 167227, updated on 8-Jul-2021

Summary

Official Symbol
DCP2provided by HGNC
Official Full Name
decapping mRNA 2provided by HGNC
Primary source
HGNC:HGNC:24452
See related
Ensembl:ENSG00000172795 MIM:609844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUDT20
Summary
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in lymph node (RPKM 7.7), placenta (RPKM 6.8) and 24 other tissues See more
Orthologs
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Genomic context

See DCP2 in Genome Data Viewer
Location:
5q22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (112976702..113022195)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112312495..112357892)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379123 Neighboring gene uncharacterized LOC105379126 Neighboring gene MCC regulator of WNT signaling pathway Neighboring gene uncharacterized LOC107986366 Neighboring gene Sharpr-MPRA regulatory region 13961 Neighboring gene testis specific serine kinase 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DCP2 decapping enzyme homolog (S. cerevisiae, DCP2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6 PubMed
gag DCP2 is associated with HIV-1 Gag and ABCE1 by immunoprecipitation analysis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-3' exoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables exoribonuclease activity, producing 5'-phosphomonoesters TAS
Traceable Author Statement
more info
 
enables m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables m7G(5')pppN diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables telomerase RNA binding IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
m7GpppN-mRNA hydrolase
Names
DCP2 decapping enzyme homolog
hDpc
mRNA-decapping enzyme 2
nudix (nucleoside diphosphate linked moiety X)-type motif 20
NP_001229306.1
NP_689837.2
XP_016864652.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029929.2 RefSeqGene

    Range
    5089..50486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242377.2NP_001229306.1  m7GpppN-mRNA hydrolase isoform 2

    See identical proteins and their annotated locations for NP_001229306.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA837315, AC008536, AL135390, AY135173, AY146650, BC045596, BC064593, BX537716, BX648838, CF994730, DB146225
    Consensus CDS
    CCDS56377.1
    UniProtKB/Swiss-Prot
    Q8IU60
    Related
    ENSP00000425770.1, ENST00000515408.5
    Conserved Domains (2) summary
    cd03672
    Location:97246
    Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
    pfam05026
    Location:1293
    DCP2; Dcp2, box A domain
  2. NM_152624.6NP_689837.2  m7GpppN-mRNA hydrolase isoform 1

    See identical proteins and their annotated locations for NP_689837.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AA837315, AC008536, AK090564, AL135390, AY135173, AY146650, BC045596, BX537716, BX648838, CF994730, DB146225
    Consensus CDS
    CCDS34210.1
    UniProtKB/Swiss-Prot
    Q8IU60
    Related
    ENSP00000373715.2, ENST00000389063.3
    Conserved Domains (2) summary
    cd03672
    Location:97246
    Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...
    pfam05026
    Location:1293
    DCP2; Dcp2, box A domain

RNA

  1. NR_038352.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal), as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA837315, AC008536, AK090564, AL135390, AY135173, AY146650, BC045596, BX537716, BX648838, CF994730, DB146225

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    112976702..113022195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009163.1XP_016864652.1  m7GpppN-mRNA hydrolase isoform X1

RNA

  1. XR_001742031.1 RNA Sequence

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