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UGT3A2 UDP glycosyltransferase family 3 member A2 [ Homo sapiens (human) ]

Gene ID: 167127, updated on 23-Nov-2021

Summary

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Official Symbol
UGT3A2provided by HGNC
Official Full Name
UDP glycosyltransferase family 3 member A2provided by HGNC
Primary source
HGNC:HGNC:27266
See related
Ensembl:ENSG00000168671 MIM:616384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in skin (RPKM 4.5), bone marrow (RPKM 1.8) and 5 other tissues See more
Orthologs
all
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Genomic context

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See UGT3A2 in Genome Data Viewer
Location:
5p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (36035021..36071358, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (36035123..36066984, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506406 Neighboring gene UDP glycosyltransferase family 3 member A1 Neighboring gene LMBR1 domain containing 2 Neighboring gene RNA, U6 small nuclear 1305, pseudogene Neighboring gene microRNA 580 Neighboring gene S-phase kinase associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes. Meech R, et al. J Biol Chem, 2012 Jul 13. PMID 22621930, Free PMC Article
  2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. Zhang X, et al. Carcinogenesis, 2010 Dec. PMID 20819778, Free PMC Article
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

See all (11) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A phenylalanine (Phe-391) in UGT3A2 favors UDP-Glc use.
    Title: Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.
  2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119426, MGC119429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables UDP-glycosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to genistein IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
UDP-glucuronosyltransferase 3A2
Names
UDP glycosyltransferase 3 family, polypeptide A2
UDPGT 3A2
NP_001161788.1
NP_777574.2
XP_011512290.1
XP_016864639.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168316.2 → NP_001161788.1  UDP-glucuronosyltransferase 3A2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This variant encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC016612, AK300751, AY358416
    Consensus CDS
    CCDS54842.1
    UniProtKB/Swiss-Prot
    Q3SY77
    Related
    ENSP00000427404.1, ENST00000513300.5
    Conserved Domains (1) summary
    cl10013
    Location:49 → 457
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

  2. NM_174914.4 → NP_777574.2  UDP-glucuronosyltransferase 3A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_777574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016612, AK075383, AY358416
    Consensus CDS
    CCDS3914.1
    UniProtKB/Swiss-Prot
    Q3SY77
    Related
    ENSP00000282507.3, ENST00000282507.8
    Conserved Domains (1) summary
    cl10013
    Location:23 → 491
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

RNA

  1. NR_031764.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016612, AK075383, AK303154, AY358416
    Related
    ENST00000504685.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    36035021..36071358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009150.1 → XP_016864639.1  UDP-glucuronosyltransferase 3A2 isoform X2

  2. XM_011513988.2 → XP_011512290.1  UDP-glucuronosyltransferase 3A2 isoform X1

    Conserved Domains (2) summary
    PHA03392
    Location:162 → 517
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:23 → 518
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SY77.1 GenPept UniProtKB/Swiss-Prot:Q3SY77

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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