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UGT3A2 UDP glycosyltransferase family 3 member A2 [ Homo sapiens (human) ]

Gene ID: 167127, updated on 5-Jul-2025
Official Symbol
UGT3A2provided by HGNC
Official Full Name
UDP glycosyltransferase family 3 member A2provided by HGNC
Primary source
HGNC:HGNC:27266
See related
Ensembl:ENSG00000168671 MIM:616384; AllianceGenome:HGNC:27266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables UDP-glycosyltransferase activity. Acts upstream of or within cellular response to genistein. Predicted to be located in membrane. Predicted to be part of UDP-N-acetylglucosamine transferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in skin (RPKM 4.5), bone marrow (RPKM 1.8) and 5 other tissues See more
Orthologs
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See UGT3A2 in Genome Data Viewer
Location:
5p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (36035021..36066882, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (36283283..36315165, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (36035123..36066984, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CAPSL divergent transcript Neighboring gene UDP glycosyltransferase family 3 member A1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:36040865-36041365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:36060047-36060547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22475 Neighboring gene LMBR1 domain containing 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:36151273-36152256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22476 Neighboring gene RNA, U6 small nuclear 1305, pseudogene Neighboring gene microRNA 580 Neighboring gene S-phase kinase associated protein 2

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC119426, MGC119429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to genistein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of UDP-N-acetylglucosamine transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
UDP-glucuronosyltransferase 3A2
Names
UDP glycosyltransferase 3 family, polypeptide A2
UDPGT 3A2
NP_001161788.1
NP_777574.2
XP_011512290.1
XP_054207854.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168316.2NP_001161788.1  UDP-glucuronosyltransferase 3A2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This variant encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC016612, AK300751, AY358416
    Consensus CDS
    CCDS54842.1
    UniProtKB/Swiss-Prot
    Q3SY77
    Related
    ENSP00000427404.1, ENST00000513300.5
    Conserved Domains (1) summary
    cl10013
    Location:49457
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
  2. NM_174914.4NP_777574.2  UDP-glucuronosyltransferase 3A2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_777574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016612, AK075383, AY358416
    Consensus CDS
    CCDS3914.1
    UniProtKB/Swiss-Prot
    B4DUQ7, E9PFK7, Q3SY77, Q6UXC4, Q8NBP2
    Related
    ENSP00000282507.3, ENST00000282507.8
    Conserved Domains (1) summary
    cl10013
    Location:23491
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

RNA

  1. NR_031764.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016612, AK075383, AK303154, AY358416
    Related
    ENST00000504685.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    36035021..36066882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513988.2XP_011512290.1  UDP-glucuronosyltransferase 3A2 isoform X1

    Conserved Domains (2) summary
    PHA03392
    Location:162517
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:23518
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    36283283..36315165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351879.1XP_054207854.1  UDP-glucuronosyltransferase 3A2 isoform X1