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CRISP1 cysteine rich secretory protein 1 [ Homo sapiens (human) ]

Gene ID: 167, updated on 11-Jun-2021

Summary

Official Symbol
CRISP1provided by HGNC
Official Full Name
cysteine rich secretory protein 1provided by HGNC
Primary source
HGNC:HGNC:304
See related
Ensembl:ENSG00000124812 MIM:601193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP; AEGL1; HUMARP; CRISP-1; HEL-S-57; HSCRISP1D; HSCRISP1G
Summary
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CRISP1 in Genome Data Viewer
Location:
6p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (49833939..49877096, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49801970..49844809, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene phosphoglycerate kinase 2 Neighboring gene uncharacterized LOC101927020 Neighboring gene uncharacterized LOC101927048 Neighboring gene defensin beta 133 (pseudogene) Neighboring gene defensin beta 114

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

General protein information

Preferred Names
cysteine-rich secretory protein 1
Names
AEG-like protein
AEG-related protein
acidic epididymal glycoprotein homolog
acidic epididymal glycoprotein-like 1
cysteine-rich secretory protein-1 delta
epididymis secretory protein Li 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131.3NP_001122.2  cysteine-rich secretory protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001122.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AL359458
    Consensus CDS
    CCDS4931.1
    UniProtKB/Swiss-Prot
    P54107
    UniProtKB/TrEMBL
    A0A0K0K1I1
    Related
    ENSP00000338276.4, ENST00000335847.9
    Conserved Domains (2) summary
    cd05383
    Location:39177
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:195249
    Crisp; Crisp
  2. NM_001205220.2NP_001192149.1  cysteine-rich secretory protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001192149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal non-coding exon, thus differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL359458, BC028577, X95237
    Consensus CDS
    CCDS4931.1
    UniProtKB/Swiss-Prot
    P54107
    UniProtKB/TrEMBL
    A0A0K0K1I1
    Related
    ENSP00000427589.1, ENST00000505118.1
    Conserved Domains (2) summary
    cd05383
    Location:39177
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:195249
    Crisp; Crisp
  3. NM_170609.2NP_733758.1  cysteine-rich secretory protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_733758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. This results in a frame-shift, early translation termination, and a shorter isoform (2, also known as CRISP-1 delta) compared to isoform 1.
    Source sequence(s)
    AL359458
    Consensus CDS
    CCDS4932.1
    UniProtKB/Swiss-Prot
    P54107
    Related
    ENSP00000425020.1, ENST00000507853.5
    Conserved Domains (1) summary
    cd05383
    Location:39178
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    49833939..49877096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514315.3XP_011512617.1  cysteine-rich secretory protein 1 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:93147
    Crisp; Crisp
    cl00133
    Location:175
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  2. XM_017010320.2XP_016865809.1  cysteine-rich secretory protein 1 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:93147
    Crisp; Crisp
    cl00133
    Location:175
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
  3. XM_017010321.2XP_016865810.1  cysteine-rich secretory protein 1 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:93147
    Crisp; Crisp
    cl00133
    Location:175
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
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