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RBM46 RNA binding motif protein 46 [ Homo sapiens (human) ]

Gene ID: 166863, updated on 23-Nov-2021

Summary

Official Symbol
RBM46provided by HGNC
Official Full Name
RNA binding motif protein 46provided by HGNC
Primary source
HGNC:HGNC:28401
See related
Ensembl:ENSG00000151962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT68
Expression
Restricted expression toward testis (RPKM 13.4) See more
Orthologs
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Genomic context

See RBM46 in Genome Data Viewer
Location:
4q32.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (154781249..154828813)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (155702424..155749965)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 pseudogene 2 Neighboring gene uncharacterized LOC105377500 Neighboring gene lecithin retinol acyltransferase Neighboring gene RNA, U2 small nuclear 66, pseudogene Neighboring gene RNA, U2 small nuclear 44, pseudogene Neighboring gene uncharacterized LOC105377501 Neighboring gene neuropeptide Y receptor Y2 Neighboring gene NPY2R antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in trophectodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable RNA-binding protein 46
Names
cancer/testis antigen 68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277171.2NP_001264100.1  probable RNA-binding protein 46 isoform 2

    See identical proteins and their annotated locations for NP_001264100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK125877, AK302720, BC028588, DB449155
    Consensus CDS
    CCDS64085.1
    UniProtKB/Swiss-Prot
    Q8TBY0
    Related
    ENSP00000424500.1, ENST00000514866.5
    Conserved Domains (4) summary
    cd12484
    Location:60137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
  2. NM_001277173.2NP_001264102.1  probable RNA-binding protein 46 isoform 3

    See identical proteins and their annotated locations for NP_001264102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate 3' terminal exon that results in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK125877, BC028588
    Consensus CDS
    CCDS64086.1
    UniProtKB/Swiss-Prot
    Q8TBY0
    Related
    ENSP00000422813.1, ENST00000510397.5
    Conserved Domains (4) summary
    cd12484
    Location:60137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
  3. NM_144979.5NP_659416.1  probable RNA-binding protein 46 isoform 1

    See identical proteins and their annotated locations for NP_659416.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC028588, DB449155, DB527978
    Consensus CDS
    CCDS3790.1
    UniProtKB/Swiss-Prot
    Q8TBY0
    Related
    ENSP00000281722.3, ENST00000281722.8
    Conserved Domains (1) summary
    cl25617
    Location:18464
    LSM_int_assoc; LSM-interacting associated unstructured

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    154781249..154828813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531695.3XP_011529997.1  probable RNA-binding protein 46 isoform X1

    See identical proteins and their annotated locations for XP_011529997.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (1) summary
    cl25617
    Location:18464
    LSM_int_assoc; LSM-interacting associated unstructured
  2. XM_006714120.1XP_006714183.1  probable RNA-binding protein 46 isoform X4

    See identical proteins and their annotated locations for XP_006714183.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (4) summary
    cd12484
    Location:60137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
  3. XM_006714119.2XP_006714182.1  probable RNA-binding protein 46 isoform X2

    See identical proteins and their annotated locations for XP_006714182.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (4) summary
    cd12484
    Location:60137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392468
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
  4. XM_011531697.2XP_011529999.1  probable RNA-binding protein 46 isoform X3

    Conserved Domains (4) summary
    cd12484
    Location:60137
    RRM1_RBM46; RNA recognition motif 1 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12492
    Location:139223
    RRM2_RBM46; RNA recognition motif 2 found in vertebrate RNA-binding protein 46 (RBM46)
    cd12496
    Location:235308
    RRM3_RBM46; RNA recognition motif 3 in vertebrate RNA-binding protein 46 (RBM46)
    pfam14709
    Location:392463
    DND1_DSRM; double strand RNA binding domain from DEAD END PROTEIN 1
  5. XM_011531693.2XP_011529995.1  probable RNA-binding protein 46 isoform X1

    See identical proteins and their annotated locations for XP_011529995.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (1) summary
    cl25617
    Location:18464
    LSM_int_assoc; LSM-interacting associated unstructured
  6. XM_011531692.2XP_011529994.1  probable RNA-binding protein 46 isoform X1

    See identical proteins and their annotated locations for XP_011529994.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (1) summary
    cl25617
    Location:18464
    LSM_int_assoc; LSM-interacting associated unstructured
  7. XM_011531694.2XP_011529996.1  probable RNA-binding protein 46 isoform X1

    See identical proteins and their annotated locations for XP_011529996.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (1) summary
    cl25617
    Location:18464
    LSM_int_assoc; LSM-interacting associated unstructured
  8. XM_011531696.2XP_011529998.1  probable RNA-binding protein 46 isoform X1

    See identical proteins and their annotated locations for XP_011529998.1

    UniProtKB/Swiss-Prot
    Q8TBY0
    Conserved Domains (1) summary
    cl25617
    Location:18464
    LSM_int_assoc; LSM-interacting associated unstructured
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