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ZBTB49 zinc finger and BTB domain containing 49 [ Homo sapiens (human) ]

Gene ID: 166793, updated on 23-Nov-2021

Summary

Official Symbol
ZBTB49provided by HGNC
Official Full Name
zinc finger and BTB domain containing 49provided by HGNC
Primary source
HGNC:HGNC:19883
See related
Ensembl:ENSG00000168826 MIM:616238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF509
Expression
Ubiquitous expression in testis (RPKM 3.0), spleen (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB49 in Genome Data Viewer
Location:
4p16.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (4290197..4321786)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (4291978..4323510)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9855 Neighboring gene Ly1 antibody reactive Neighboring gene uncharacterized LOC112268462 Neighboring gene neuronal vesicle trafficking associated 1 Neighboring gene uncharacterized LOC107986253

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38559, MGC126279, MGC126280

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 49
Names
zinc finger protein 509

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330625.2NP_001317554.1  zinc finger and BTB domain-containing protein 49

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK292551, BC109087, CA435417
    Consensus CDS
    CCDS3375.1
    UniProtKB/Swiss-Prot
    Q6ZSB9
  2. NM_145291.4NP_660334.3  zinc finger and BTB domain-containing protein 49

    See identical proteins and their annotated locations for NP_660334.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK292551, BC109087, CA435417
    Consensus CDS
    CCDS3375.1
    UniProtKB/Swiss-Prot
    Q6ZSB9
    Related
    ENSP00000338807.4, ENST00000337872.9
    Conserved Domains (6) summary
    smart00225
    Location:26119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:384542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:509529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:15118
    BTB; BTB/POZ domain
    pfam13465
    Location:549574
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_138481.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK292551, BC109087, CA435417
    Related
    ENST00000515012.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    4290197..4321786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513416.1XP_011511718.1  zinc finger and BTB domain-containing protein 49 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZSB9
    Conserved Domains (5) summary
    smart00225
    Location:26119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:397417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:15118
    BTB; BTB/POZ domain
    pfam13465
    Location:427452
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005247951.4XP_005248008.1  zinc finger and BTB domain-containing protein 49 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZSB9
    Conserved Domains (5) summary
    smart00225
    Location:26119
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:397417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:15118
    BTB; BTB/POZ domain
    pfam13465
    Location:409434
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024453916.1XP_024309684.1  zinc finger and BTB domain-containing protein 49 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:397417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:15119
    BTB; BTB/POZ domain

RNA

  1. XR_241646.4 RNA Sequence

  2. XR_001741154.1 RNA Sequence

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