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TRIM60 tripartite motif containing 60 [ Homo sapiens (human) ]

Gene ID: 166655, updated on 7-Jun-2020

Summary

Official Symbol
TRIM60provided by HGNC
Official Full Name
tripartite motif containing 60provided by HGNC
Primary source
HGNC:HGNC:21162
See related
Ensembl:ENSG00000176979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF33; RNF129
Summary
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TRIM60 in Genome Data Viewer
Location:
4q32.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (165031953..165041821)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (165953151..165962896)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene tripartite motif-containing 75 pseudogene Neighboring gene tripartite motif containing 75, pseudogene Neighboring gene transmembrane protein 192

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35882, MGC119325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 60
Names
ring finger protein 129
ring finger protein 33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258025.2NP_001244954.1  tripartite motif-containing protein 60

    See identical proteins and their annotated locations for NP_001244954.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC106872, BC100986
    Consensus CDS
    CCDS3808.1
    UniProtKB/Swiss-Prot
    Q495X7
    Related
    ENSP00000426496.1, ENST00000508504.1
    Conserved Domains (5) summary
    cd15828
    Location:286465
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    pfam00643
    Location:92133
    zf-B_box; B-box zinc finger
    pfam15905
    Location:139260
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    cd16607
    Location:1359
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
    cl26688
    Location:16105
    DWNN; DWNN domain
  2. NM_152620.3NP_689833.1  tripartite motif-containing protein 60

    See identical proteins and their annotated locations for NP_689833.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC106872, AK093201
    Consensus CDS
    CCDS3808.1
    UniProtKB/Swiss-Prot
    Q495X7
    Related
    ENSP00000421142.1, ENST00000512596.6
    Conserved Domains (5) summary
    cd15828
    Location:286465
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    pfam00643
    Location:92133
    zf-B_box; B-box zinc finger
    pfam15905
    Location:139260
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    cd16607
    Location:1359
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
    cl26688
    Location:16105
    DWNN; DWNN domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    165031953..165041821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531683.2XP_011529985.1  tripartite motif-containing protein 60 isoform X1

    See identical proteins and their annotated locations for XP_011529985.1

    UniProtKB/Swiss-Prot
    Q495X7
    Conserved Domains (5) summary
    cd15828
    Location:286465
    SPRY_PRY_TRIM60; PRY/SPRY domain of tripartite motif-binding protein 60 (TRIM60) also known as RING finger protein 33 (RNF33)
    pfam00643
    Location:92133
    zf-B_box; B-box zinc finger
    pfam15905
    Location:139260
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    cd16607
    Location:1359
    RING-HC_TRIM60_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM60, TRIM61 and similar proteins
    cl26688
    Location:16105
    DWNN; DWNN domain
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