Format

Send to:

Choose Destination

ADGRA3 adhesion G protein-coupled receptor A3 [ Homo sapiens (human) ]

Gene ID: 166647, updated on 5-Aug-2018

Summary

Official Symbol
ADGRA3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor A3provided by HGNC
Primary source
HGNC:HGNC:13839
See related
Ensembl:ENSG00000152990 MIM:612303; Vega:OTTHUMG00000160926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR21; TEM5L; GPR125
Summary
This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in thyroid (RPKM 9.5), liver (RPKM 6.2) and 24 other tissues See more
Orthologs

Genomic context

See ADGRA3 in Genome Data Viewer
Location:
4p15.2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (22387374..22516058, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (22388997..22517677, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505912 Neighboring gene uncharacterized LOC105374519 Neighboring gene ribosomal protein S27 pseudogene 13 Neighboring gene uncharacterized LOC105374520

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ADGRA3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor A3
Names
G-protein coupled receptor 125
probable G-protein coupled receptor 125

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032963.1 RefSeqGene

    Range
    5001..133681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_145290.3NP_660333.2  adhesion G protein-coupled receptor A3 precursor

    See identical proteins and their annotated locations for NP_660333.2

    Status: REVIEWED

    Source sequence(s)
    AC093814, AI198439, AL832257, BC035645
    Consensus CDS
    CCDS33964.1
    UniProtKB/Swiss-Prot
    Q8IWK6
    Related
    ENSP00000334952.5, OTTHUMP00000219285, ENST00000334304.9, OTTHUMT00000362960
    Conserved Domains (10) summary
    cd00096
    Location:262337
    Ig; Immunoglobulin domain
    smart00082
    Location:189223
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:249341
    IG_like; Immunoglobulin like
    cd00116
    Location:70182
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:83106
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:704743
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:363416
    HRM; Hormone receptor domain
    pfam12799
    Location:107146
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:85141
    LRR_8; Leucine rich repeat
    cl21561
    Location:796945
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    22387374..22516058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513811.2XP_011512113.1  adhesion G protein-coupled receptor A3 isoform X1

    Conserved Domains (5) summary
    cd00096
    Location:36111
    Ig; Immunoglobulin domain
    smart00410
    Location:23115
    IG_like; Immunoglobulin like
    pfam01825
    Location:478517
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:137190
    HRM; Hormone receptor domain
    cl21561
    Location:570719
    7tm_4; Olfactory receptor
  2. XM_005248137.5XP_005248194.1  adhesion G protein-coupled receptor A3 isoform X2

    Conserved Domains (9) summary
    cd00096
    Location:262337
    Ig; Immunoglobulin domain
    smart00082
    Location:189223
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:249341
    IG_like; Immunoglobulin like
    cd00116
    Location:84166
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:83106
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:704743
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:363416
    HRM; Hormone receptor domain
    pfam12799
    Location:107146
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:85141
    LRR_8; Leucine rich repeat

RNA

  1. XR_001741153.1 RNA Sequence

Support Center