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Krt10 keratin 10 [ Mus musculus (house mouse) ]

Gene ID: 16661, updated on 14-May-2024

Summary

Official Symbol
Krt10provided by MGI
Official Full Name
keratin 10provided by MGI
Primary source
MGI:MGI:96685
See related
Ensembl:ENSMUSG00000019761 AllianceGenome:MGI:96685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K10; K1C1; Krt1-10; Krt-1.10; D130054E02Rik
Summary
Enables cytoskeletal protein binding activity. Involved in positive regulation of epidermis development. Acts upstream of or within cellular response to calcium ion; intermediate filament organization; and keratinocyte development. Located in keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; respiratory system; sensory organ; and skin. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 238.7) and limb E14.5 (RPKM 51.3) See more
Orthologs
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Genomic context

See Krt10 in Genome Data Viewer
Location:
11 D; 11 62.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99276080..99288631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99385254..99397449, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 27 Neighboring gene keratin 28 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247019-99247320 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247331-99247631 Neighboring gene RIKEN cDNA A830036E02 gene Neighboring gene keratin 12 Neighboring gene keratin 20

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of skin epidermis ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in cornified envelope ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in keratin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 10
Names
56 kDa cytokeratin
CK-10
cytokeratin-10
epidermal keratin 10
intermediate filament protein
keratin complex 1, acidic, gene 10
keratin, type I cytoskeletal 59 kDa
suprabasal cytokeratin 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010660.2NP_034790.2  keratin, type I cytoskeletal 10

    See identical proteins and their annotated locations for NP_034790.2

    Status: VALIDATED

    Source sequence(s)
    AI173281, AK076508, BB648004
    Consensus CDS
    CCDS25380.1
    UniProtKB/TrEMBL
    A2A513
    Related
    ENSMUSP00000099420.5, ENSMUST00000103131.5
    Conserved Domains (1) summary
    pfam00038
    Location:134443
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99276080..99288631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248768.3XP_011247070.1  keratin, type I cytoskeletal 10 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:134443
    Filament; Intermediate filament protein