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Kpna3 karyopherin (importin) alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 16648, updated on 9-Mar-2023

Summary

Official Symbol
Kpna3provided by MGI
Official Full Name
karyopherin (importin) alpha 3provided by MGI
Primary source
MGI:MGI:1100863
See related
Ensembl:ENSMUSG00000021929 AllianceGenome:MGI:1100863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IPOA4
Summary
Enables protein C-terminus binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including gonad; heart; liver; lung; and spleen. Orthologous to human KPNA3 (karyopherin subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 19.9), CNS E18 (RPKM 18.5) and 24 other tissues See more
Orthologs
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Genomic context

See Kpna3 in Genome Data Viewer
Location:
14; 14 D1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61602635..61677396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (61365186..61439947, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5461 Neighboring gene predicted gene, 25716 Neighboring gene emopamil binding protein-like Neighboring gene ribosomal protein S12, pseudogene 2 Neighboring gene predicted gene, 41169

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
importin subunit alpha-4
Names
importin alpha 4
importin alpha Q2
importin subunit alpha-3
karyopherin subunit alpha-3
qip2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008466.5NP_032492.1  importin subunit alpha-4

    See identical proteins and their annotated locations for NP_032492.1

    Status: VALIDATED

    Source sequence(s)
    AC154435, AK049373, AV581906
    Consensus CDS
    CCDS36942.1
    UniProtKB/Swiss-Prot
    O35344
    UniProtKB/TrEMBL
    A0A6P5QYT5, A0A8C6I120, Q543M7
    Related
    ENSMUSP00000022496.8, ENSMUST00000022496.9
    Conserved Domains (2) summary
    COG5064
    Location:7521
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:244269
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    61602635..61677396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)