U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kpna2 karyopherin (importin) alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 16647, updated on 5-Feb-2023

Summary

Official Symbol
Kpna2provided by MGI
Official Full Name
karyopherin (importin) alpha 2provided by MGI
Primary source
MGI:MGI:103561
See related
Ensembl:ENSMUSG00000018362 AllianceGenome:MGI:103561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rch1; IPOA1; PTAC58; 2410044B12Rik
Summary
Enables DNA-binding transcription factor binding activity and nuclear import signal receptor activity. Acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of viral life cycle; and protein import into nucleus. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 144.8), liver E14 (RPKM 99.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kpna2 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106879455..106890351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106988629..106999525, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene predicted gene, 39424 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCG)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC91246

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
importin subunit alpha-1
Names
RAG cohort protein 1
SRP1-alpha
importin alpha 1
importin alpha P1
importin subunit alpha-2
karyopherin subunit alpha-2
m-importin-alpha-P1
pendulin
pore targeting complex 58 kDa subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010655.3NP_034785.1  importin subunit alpha-1

    See identical proteins and their annotated locations for NP_034785.1

    Status: VALIDATED

    Source sequence(s)
    AI664586, AK075952, BC086789
    Consensus CDS
    CCDS25565.1
    UniProtKB/Swiss-Prot
    P52293, Q64292
    UniProtKB/TrEMBL
    A0A8C6GEN3, Q52L97
    Related
    ENSMUSP00000018506.7, ENSMUST00000018506.13
    Conserved Domains (6) summary
    COG5064
    Location:9528
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:113238
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:1098
    IBB; Importin beta binding domain
    pfam16186
    Location:458508
    Arm_3; Atypical Arm repeat
    sd00044
    Location:457494
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:115147
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106879455..106890351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)