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Kng1 kininogen 1 [ Mus musculus (house mouse) ]

Gene ID: 16644, updated on 8-Dec-2022

Summary

Official Symbol
Kng1provided by MGI
Official Full Name
kininogen 1provided by MGI
Primary source
MGI:MGI:1097705
See related
Ensembl:ENSMUSG00000022875 AllianceGenome:MGI:1097705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kng
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity; protease binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including blood coagulation; negative regulation of peptidase activity; and vasodilation. Located in collagen-containing extracellular matrix. Is expressed in yolk sac. Human ortholog(s) of this gene implicated in high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 646.0), liver adult (RPKM 179.1) and 3 other tissues See more
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Genomic context

See Kng1 in Genome Data Viewer
Location:
16; 16 B1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22876970..22900828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23058220..23082078)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene tryptophan rich basic protein pseudogene Neighboring gene ribosomal protein S3 pseudogene Neighboring gene AT rich interactive domain 1A (SWI-like) pseudogene Neighboring gene predicted gene, 30693 Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene small nucleolar RNA, C/D box 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC123437

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kininogen-1
Names
H-kininigen
L-kininogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102411.1NP_001095881.1  kininogen-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001095881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as HMW kininogen-I.
    Source sequence(s)
    AC154540, BC108936
    Consensus CDS
    CCDS49804.1
    UniProtKB/Swiss-Prot
    O08677
    UniProtKB/TrEMBL
    A0A0R4J038
    Related
    ENSMUSP00000023589.9, ENSMUST00000023589.15
    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain
  2. NM_001102412.1NP_001095882.1  kininogen-1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA277668, AC154540, AK005547
    Consensus CDS
    CCDS49803.1
    UniProtKB/TrEMBL
    D3YTY9
    Related
    ENSMUSP00000087346.7, ENSMUST00000089902.8
    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain
  3. NM_023125.3NP_075614.1  kininogen-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_075614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2), also known as LMW kininogen-I, has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154540, AK005547, BY463622
    Consensus CDS
    CCDS28073.1
    UniProtKB/Swiss-Prot
    O08677
    Related
    ENSMUSP00000040485.7, ENSMUST00000039492.14
    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22876970..22900828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248988.1XP_030104848.1  kininogen-1 isoform X2

    Conserved Domains (1) summary
    smart00043
    Location:141284
    CY; Cystatin-like domain
  2. XM_006521813.1XP_006521876.1  kininogen-1 isoform X3

    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain
  3. XM_006521812.3XP_006521875.1  kininogen-1 isoform X1

    Conserved Domains (1) summary
    smart00043
    Location:141284
    CY; Cystatin-like domain