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DDX11 DEAD/H-box helicase 11 [ Homo sapiens (human) ]

Gene ID: 1663, updated on 11-Sep-2019

Summary

Official Symbol
DDX11provided by HGNC
Official Full Name
DEAD/H-box helicase 11provided by HGNC
Primary source
HGNC:HGNC:2736
See related
Ensembl:ENSG00000013573 MIM:601150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHL1; KRG2; WABS; CHLR1
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 6.8), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See DDX11 in Genome Data Viewer
Location:
12p11.21
Exon count:
33
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (31073860..31104799)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31226779..31257733)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tetraspanin 11 Neighboring gene DDX11 antisense RNA 1 Neighboring gene putative uncharacterized protein FLJ45355 Neighboring gene alpha-2-macroglobulin like 1 pseudogene Neighboring gene uncharacterized LOC107987168

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
nucleocapsid gag DDX11 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
    IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
    Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
  • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
    XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9335, MGC133249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication origin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-quadruplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
triplex DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA duplex unwinding IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
G-quadruplex DNA unwinding IDA
Inferred from Direct Assay
more info
PubMed 
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to bleomycin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cisplatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hydroxyurea IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleolar chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication fork processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid cohesion IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with Ctf18 RFC-like complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with mitotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent DNA helicase DDX11
Names
CHL1-like helicase homolog
CHL1-related helicase gene-1
CHL1-related protein 1
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)
DEAD/H box protein 11
KRG-2
hCHLR1
keratinocyte growth factor-regulated gene 2 protein
probable ATP-dependent DNA helicase DDX11
probable ATP-dependent RNA helicase DDX11
NP_001244073.1
NP_001244074.1
NP_004390.3
NP_085911.2
NP_689651.1
XP_005253388.1
XP_005253390.1
XP_006719113.1
XP_011518894.1
XP_011518897.1
XP_011518899.1
XP_016874407.1
XP_016874408.1
XP_016874409.1
XP_016874410.1
XP_016874411.1
XP_016874412.1
XP_016874413.1
XP_016874414.1
XP_016874415.1
XP_016874416.1
XP_016874417.1
XP_016874418.1
XP_016874419.1
XP_016874420.1
XP_016874421.1
XP_016874422.1
XP_016874423.1
XP_016874424.1
XP_016874425.1
XP_016874426.1
XP_016874427.1
XP_016874428.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023352.1 RefSeqGene

    Range
    5016..35955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257144.2NP_001244073.1  ATP-dependent DNA helicase DDX11 isoform 3

    See identical proteins and their annotated locations for NP_001244073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC008013, BC050522
    Consensus CDS
    CCDS44856.1
    UniProtKB/Swiss-Prot
    Q96FC9
    Related
    ENSP00000440402.1, ENST00000545668.5
    Conserved Domains (1) summary
    cl26947
    Location:227822
    HBB; Helical and beta-bridge domain
  2. NM_001257145.2NP_001244074.1  ATP-dependent DNA helicase DDX11 isoform 4

    See identical proteins and their annotated locations for NP_001244074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, and uses a downstream AUG compared to variant 3. The resulting protein (isoform 4) has shorter N- and C-termini compared to isoform 3.
    Source sequence(s)
    AC008013, BC050069
    Consensus CDS
    CCDS58224.1
    UniProtKB/Swiss-Prot
    Q96FC9
    Related
    ENSP00000228264.6, ENST00000228264.10
    Conserved Domains (3) summary
    smart00488
    Location:1411
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:201867
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:666853
    Helicase_C_2; Helicase C-terminal domain
  3. NM_004399.3NP_004390.3  ATP-dependent DNA helicase DDX11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 3, that results in a frameshift. The resulting isoform (2) lacks an internal segment and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC008013, BC011264, BC111733, X99583
    Consensus CDS
    CCDS8721.1
    UniProtKB/Swiss-Prot
    Q96FC9
    UniProtKB/TrEMBL
    Q2NKM7
    Related
    ENSP00000309965.5, ENST00000350437.8
    Conserved Domains (3) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:680817
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:227843
    rad3; DNA repair helicase (rad3)
  4. NM_030653.4NP_085911.2  ATP-dependent DNA helicase DDX11 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice junction at a coding exon compared to variant 3, that results in a frameshift. The resulting isoform (1) is shorter and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC008013, BC011264, BC111733
    Consensus CDS
    CCDS41767.1
    UniProtKB/TrEMBL
    Q2NKM7
    Related
    ENSP00000443426.1, ENST00000542838.6
    Conserved Domains (3) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:227893
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:692879
    Helicase_C_2; Helicase C-terminal domain
  5. NM_152438.2NP_689651.1  ATP-dependent DNA helicase DDX11 isoform 3

    See identical proteins and their annotated locations for NP_689651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3). Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC008013, BC011264, BC111733
    Consensus CDS
    CCDS44856.1
    UniProtKB/Swiss-Prot
    Q96FC9
    UniProtKB/TrEMBL
    Q2NKM7
    Conserved Domains (1) summary
    cl26947
    Location:227822
    HBB; Helical and beta-bridge domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    31073860..31104799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018923.1XP_016874412.1  ATP-dependent DNA helicase DDX11 isoform X4

  2. XM_017018932.1XP_016874421.1  ATP-dependent DNA helicase DDX11 isoform X15

    UniProtKB/Swiss-Prot
    Q96FC9
    Conserved Domains (3) summary
    smart00488
    Location:11437
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:227893
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:692879
    Helicase_C_2; Helicase C-terminal domain
  3. XM_017018922.1XP_016874411.1  ATP-dependent DNA helicase DDX11 isoform X4

  4. XM_017018931.1XP_016874420.1  ATP-dependent DNA helicase DDX11 isoform X14

  5. XM_017018934.1XP_016874423.1  ATP-dependent DNA helicase DDX11 isoform X18

  6. XM_017018933.2XP_016874422.1  ATP-dependent DNA helicase DDX11 isoform X17

  7. XM_017018919.2XP_016874408.1  ATP-dependent DNA helicase DDX11 isoform X1

  8. XM_017018924.2XP_016874413.1  ATP-dependent DNA helicase DDX11 isoform X4

  9. XM_017018925.1XP_016874414.1  ATP-dependent DNA helicase DDX11 isoform X4

  10. XM_017018920.2XP_016874409.1  ATP-dependent DNA helicase DDX11 isoform X2

  11. XM_017018926.2XP_016874415.1  ATP-dependent DNA helicase DDX11 isoform X5

  12. XM_017018929.2XP_016874418.1  ATP-dependent DNA helicase DDX11 isoform X9

  13. XM_017018927.2XP_016874416.1  ATP-dependent DNA helicase DDX11 isoform X6

  14. XM_017018918.2XP_016874407.1  ATP-dependent DNA helicase DDX11 isoform X1

  15. XM_017018928.2XP_016874417.1  ATP-dependent DNA helicase DDX11 isoform X8

  16. XM_017018921.2XP_016874410.1  ATP-dependent DNA helicase DDX11 isoform X3

  17. XM_017018930.2XP_016874419.1  ATP-dependent DNA helicase DDX11 isoform X11

  18. XM_017018938.2XP_016874427.1  ATP-dependent DNA helicase DDX11 isoform X20

  19. XM_017018939.2XP_016874428.1  ATP-dependent DNA helicase DDX11 isoform X21

  20. XM_011520592.3XP_011518894.1  ATP-dependent DNA helicase DDX11 isoform X7

    See identical proteins and their annotated locations for XP_011518894.1

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746860
    HELICc2; helicase superfamily c-terminal domain
  21. XM_006719050.4XP_006719113.1  ATP-dependent DNA helicase DDX11 isoform X12

    Conserved Domains (3) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:263929
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:728915
    Helicase_C_2; Helicase C-terminal domain
  22. XM_005253331.4XP_005253388.1  ATP-dependent DNA helicase DDX11 isoform X10

    Conserved Domains (2) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:746860
    HELICc2; helicase superfamily c-terminal domain
  23. XM_011520595.3XP_011518897.1  ATP-dependent DNA helicase DDX11 isoform X16

    Conserved Domains (3) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    smart00491
    Location:716853
    HELICc2; helicase superfamily c-terminal domain
    TIGR00604
    Location:263879
    rad3; DNA repair helicase (rad3)
  24. XM_011520597.3XP_011518899.1  ATP-dependent DNA helicase DDX11 isoform X22

    Conserved Domains (1) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
  25. XM_005253333.4XP_005253390.1  ATP-dependent DNA helicase DDX11 isoform X13

    Conserved Domains (3) summary
    smart00488
    Location:47473
    DEXDc2; DEAD-like helicases superfamily
    TIGR00604
    Location:263929
    rad3; DNA repair helicase (rad3)
    pfam13307
    Location:728915
    Helicase_C_2; Helicase C-terminal domain
  26. XM_017018935.1XP_016874424.1  ATP-dependent DNA helicase DDX11 isoform X19

  27. XM_017018936.1XP_016874425.1  ATP-dependent DNA helicase DDX11 isoform X19

  28. XM_017018937.1XP_016874426.1  ATP-dependent DNA helicase DDX11 isoform X19

RNA

  1. XR_001748607.2 RNA Sequence

  2. XR_001748611.2 RNA Sequence

  3. XR_001748608.2 RNA Sequence

  4. XR_001748609.2 RNA Sequence

  5. XR_001748610.2 RNA Sequence

  6. XR_001748606.2 RNA Sequence

  7. XR_001748617.2 RNA Sequence

  8. XR_002957297.1 RNA Sequence

  9. XR_001748615.2 RNA Sequence

  10. XR_001748616.2 RNA Sequence

  11. XR_001748613.2 RNA Sequence

  12. XR_001748614.2 RNA Sequence

  13. XR_002957298.1 RNA Sequence

  14. XR_429031.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030655.2: Suppressed sequence

    Description
    NM_030655.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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