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Klkb1 kallikrein B, plasma 1 [ Mus musculus (house mouse) ]

Gene ID: 16621, updated on 8-Dec-2018

Summary

Official Symbol
Klkb1provided by MGI
Official Full Name
kallikrein B, plasma 1provided by MGI
Primary source
MGI:MGI:102849
See related
Ensembl:ENSMUSG00000109764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APS; PSA; Kal3; Klk3; Kal-3
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]
Expression
Biased expression in liver adult (RPKM 26.3), liver E18 (RPKM 18.5) and 2 other tissues See more
Orthologs

Genomic context

See Klkb1 in Genome Data Viewer
Location:
8 B1.1; 8 25.17 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (45266688..45294835, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (46354796..46380189, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30504 Neighboring gene predicted gene 6329 Neighboring gene coagulation factor XI Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3 Neighboring gene family with sequence similarity 149, member A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Potential readthrough

Included gene: Cyp4v3

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
blood coagulation, intrinsic pathway IEA
Inferred from Electronic Annotation
more info
 
fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plasma kallikrein
Names
antigen, prostate specific
fletcher factor
kallikrein 3, plasma
kininogenin
plasma prekallikrein
NP_032481.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008455.3NP_032481.2  plasma kallikrein preproprotein

    See identical proteins and their annotated locations for NP_032481.2

    Status: REVIEWED

    Source sequence(s)
    AC120003
    Consensus CDS
    CCDS22275.1
    UniProtKB/Swiss-Prot
    P26262
    UniProtKB/TrEMBL
    H9H9R5
    Related
    ENSMUSP00000026907.5, ENSMUST00000026907.5
    Conserved Domains (3) summary
    smart00223
    Location:21104
    APPLE; APPLE domain
    smart00020
    Location:390621
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:391621
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    45266688..45294835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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