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CHST13 carbohydrate sulfotransferase 13 [ Homo sapiens (human) ]

Gene ID: 166012, updated on 11-Sep-2019

Summary

Official Symbol
CHST13provided by HGNC
Official Full Name
carbohydrate sulfotransferase 13provided by HGNC
Primary source
HGNC:HGNC:21755
See related
Ensembl:ENSG00000180767 MIM:610124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4ST3
Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]
Expression
Biased expression in liver (RPKM 5.7), testis (RPKM 3.2) and 4 other tissues See more
Orthologs

Genomic context

See CHST13 in Genome Data Viewer
Location:
3q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (126524155..126543291)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (126243131..126262134)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ZXD family zinc finger C Neighboring gene urocanate hydratase 1 Neighboring gene chromosome 3 open reading frame 22 Neighboring gene uncharacterized LOC105374090 Neighboring gene RNA, 5S ribosomal pseudogene 138 Neighboring gene methyltransferase like 5 pseudogene Neighboring gene thioredoxin reductase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of carbohydrate sulfotransferase 13 (CHST13) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC119278, MGC119279, MGC119281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylgalactosamine 4-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin 4-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
chondroitin sulfate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 13
Names
C4ST-3
carbohydrate (chondroitin 4) sulfotransferase 13
chondroitin 4-O-sulfotransferase 3
chondroitin 4-sulfotransferase 3
NP_690849.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029855.1 RefSeqGene

    Range
    4868..24004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152889.3NP_690849.1  carbohydrate sulfotransferase 13 precursor

    See identical proteins and their annotated locations for NP_690849.1

    Status: REVIEWED

    Source sequence(s)
    AC024558, AY120869, DR006930
    Consensus CDS
    CCDS3039.1
    UniProtKB/Swiss-Prot
    Q8NET6
    Related
    ENSP00000317404.2, ENST00000319340.6
    Conserved Domains (1) summary
    pfam03567
    Location:102332
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    126524155..126543291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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