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Klf9 Kruppel-like transcription factor 9 [ Mus musculus (house mouse) ]

Gene ID: 16601, updated on 11-Jun-2025
Official Symbol
Klf9provided by MGI
Official Full Name
Kruppel-like transcription factor 9provided by MGI
Primary source
MGI:MGI:1333856
See related
Ensembl:ENSMUSG00000033863 AllianceGenome:MGI:1333856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bteb1; BTEB-1; Gm9971; 2310051E17Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryo implantation; progesterone receptor signaling pathway; and retinoic acid catabolic process. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and skeleton. Orthologous to human KLF9 (KLF transcription factor 9). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Broad expression in lung adult (RPKM 44.8), adrenal adult (RPKM 44.1) and 21 other tissues See more
Orthologs
human all
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See Klf9 in Genome Data Viewer
Location:
19 B; 19 17.9 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23118590..23145493)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23141226..23168129)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene RIKEN cDNA C330002G04 gene Neighboring gene STARR-seq mESC enhancer starr_45752 Neighboring gene STARR-seq mESC enhancer starr_45755 Neighboring gene STARR-seq mESC enhancer starr_45757 Neighboring gene STARR-seq mESC enhancer starr_45759 Neighboring gene STARR-seq mESC enhancer starr_45760 Neighboring gene RIKEN cDNA 2410080I02 gene Neighboring gene STARR-seq mESC enhancer starr_45763 Neighboring gene STARR-positive B cell enhancer ABC_E4273 Neighboring gene STARR-seq mESC enhancer starr_45766 Neighboring gene STARR-seq mESC enhancer starr_45769 Neighboring gene STARR-seq mESC enhancer starr_45772 Neighboring gene microRNA 1192 Neighboring gene STARR-positive B cell enhancer mm9_chr19:23348377-23348678 Neighboring gene structural maintenance of chromosomes 5 Neighboring gene predicted gene, 33950 Neighboring gene predicted gene, 24263

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Klf9 is essential for cardiac mitochondrial homeostasis. Zhang L, et al. Nat Cardiovasc Res, 2024 Nov. PMID 39528719
  2. Klf9 is necessary and sufficient for Purkinje cell survival in organotypic culture. Lebrun C, et al. Mol Cell Neurosci, 2013 May. PMID 23201237
  3. Functional analysis of basic transcription element binding protein by gene targeting technology. Morita M, et al. Mol Cell Biol, 2003 Apr. PMID 12640131, Free PMC Article
  4. Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9. Simmen FA, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Jun. PMID 17379758
  5. [KLF9 regulates hepatic lipid metabolism via inducing CD36 expression]. Zhou SS, et al. Sheng Li Xue Bao, 2021 Oct 25. PMID 34708234

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
    Title: Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
  2. Mechanism of KLF9 in airway inflammation in chronic obstructive pulmonary.
    Title: Mechanism of KLF9 in airway inflammation in chronic obstructive pulmonary.
  3. MicroRNA-30a-5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.
    Title: MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.
  4. Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
    Title: Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
  5. KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
    Title: KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
  6. KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARgamma/NRF2 Signalling.
    Title: KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling.
  7. Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression.
    Title: Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression.
  8. Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression.
    Title: Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression.
  9. microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis.
    Title: microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis.
  10. An Intact Kruppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress.
    Title: An Intact Krüppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to cortisol stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to cortisol stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within embryo implantation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinoic acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
Krueppel-like factor 9
Names
BTE-binding protein 1
GC-box-binding protein 1
Kruppel-like factor 9
basic transcription element binding protein 1
transcription factor BTEB1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010638.5 → NP_034768.2  Krueppel-like factor 9

    See identical proteins and their annotated locations for NP_034768.2

    Status: VALIDATED

    Source sequence(s)
    AC121973
    Consensus CDS
    CCDS29706.1
    UniProtKB/Swiss-Prot
    O35739
    UniProtKB/TrEMBL
    Q8CEC4
    Related
    ENSMUSP00000045639.2, ENSMUST00000036884.3
    Conserved Domains (2) summary
    COG5048
    Location:78 → 234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:145 → 167
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    23118590..23145493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35739.1 GenPept UniProtKB/Swiss-Prot:O35739

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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