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Klf1 Kruppel-like transcription factor 1 (erythroid) [ Mus musculus (house mouse) ]

Gene ID: 16596, updated on 7-Apr-2024

Summary

Official Symbol
Klf1provided by MGI
Official Full Name
Kruppel-like transcription factor 1 (erythroid)provided by MGI
Primary source
MGI:MGI:1342771
See related
Ensembl:ENSMUSG00000054191 AllianceGenome:MGI:1342771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nan; Eklf
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including chromatin remodeling; hemopoiesis; and liver development. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 150.9), liver E14 (RPKM 122.7) and 2 other tissues See more
Orthologs
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Genomic context

See Klf1 in Genome Data Viewer
Location:
8 41.3 cM; 8 C3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85628611..85631920)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84901982..84905291)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11391 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene predicted gene, 39213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene STARR-positive B cell enhancer ABC_E1373 Neighboring gene deoxyribonuclease II alpha Neighboring gene predicted gene, 38426 Neighboring gene microtubule associated serine/threonine kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 1
Names
Kruppel-like factor 1 (erythroid)
erythroid krueppel-like transcription factor
erythroid transcription factor
neonatal anemia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010635.3NP_034765.3  Krueppel-like factor 1

    Status: VALIDATED

    Source sequence(s)
    AC161765
    Consensus CDS
    CCDS22483.1
    UniProtKB/Swiss-Prot
    O70261, P46099
    UniProtKB/TrEMBL
    E9QNP6
    Related
    ENSMUSP00000064366.9, ENSMUST00000067060.10
    Conserved Domains (4) summary
    COG5048
    Location:279357
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:280299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam16832
    Location:2239
    EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
    pfam16833
    Location:6385
    EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85628611..85631920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)