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Uhmk1 U2AF homology motif (UHM) kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16589, updated on 26-Sep-2022

Summary

Official Symbol
Uhmk1provided by MGI
Official Full Name
U2AF homology motif (UHM) kinase 1provided by MGI
Primary source
MGI:MGI:1341908
See related
Ensembl:ENSMUSG00000026667 AllianceGenome:MGI:1341908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KIS; Kist; P-CIP2; 4732477C12Rik; 4930500M09Rik; C820018A03Rik
Summary
Enables ribonucleoprotein complex binding activity. Involved in neuron projection development and positive regulation of translational initiation. Located in axon; dendrite cytoplasm; and neuronal ribonucleoprotein granule. Is expressed in brain; heart; liver; metanephros; and musculature. Orthologous to human UHMK1 (U2AF homology motif kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.7), ovary adult (RPKM 8.9) and 28 other tissues See more
Orthologs
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Genomic context

See Uhmk1 in Genome Data Viewer
Location:
1; 1 H3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170020989..170043466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170193422..170215897, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene discoidin domain receptor family, member 2 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 Neighboring gene SH2 domain containing 1B2 Neighboring gene predicted gene 6345

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables splicing factor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Kist
Names
PAM COOH-terminal interactor protein 2
U2AF homology motif kinase 1
kinase interacting with leukemia-associated gene (stathmin)
kinase interacting with stathmin
NP_001347738.1
NP_034763.3
XP_006496745.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360809.1NP_001347738.1  serine/threonine-protein kinase Kist isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC123650, AK030152
    Consensus CDS
    CCDS87917.1
    UniProtKB/TrEMBL
    A0A8C6H362, Q8C0N6
    Related
    ENSMUSP00000115622.2, ENSMUST00000150821.8
    Conserved Domains (2) summary
    cd12465
    Location:229316
    RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
    cl21453
    Location:1219
    PKc_like; Protein Kinases, catalytic domain
  2. NM_010633.4NP_034763.3  serine/threonine-protein kinase Kist isoform 1

    See identical proteins and their annotated locations for NP_034763.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123650, BC058732
    Consensus CDS
    CCDS15468.1
    UniProtKB/Swiss-Prot
    P97343, Q9CYT1
    UniProtKB/TrEMBL
    A0A6P5PDV8, A0A8C6MUZ1
    Related
    ENSMUSP00000027979.8, ENSMUST00000027979.14
    Conserved Domains (2) summary
    cd12465
    Location:318405
    RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
    cd14020
    Location:22308
    STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170020989..170043466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496682.4XP_006496745.1  serine/threonine-protein kinase Kist isoform X1

    UniProtKB/TrEMBL
    A0A8C6H0W8, D3YUF5
    Related
    ENSMUSP00000120787.2, ENSMUST00000123399.2
    Conserved Domains (2) summary
    cd14020
    Location:22308
    STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)
    cl17169
    Location:318341
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_004940648.1 RNA Sequence

  2. XR_004940646.1 RNA Sequence