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Kin Kin17 DNA and RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 16588, updated on 9-Mar-2023

Summary

Official Symbol
Kinprovided by MGI
Official Full Name
Kin17 DNA and RNA binding proteinprovided by MGI
Primary source
MGI:MGI:96676
See related
Ensembl:ENSMUSG00000037262 AllianceGenome:MGI:96676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kin17
Summary
Enables double-stranded DNA binding activity. Involved in DNA replication. Acts upstream of or within cellular response to DNA damage stimulus. Located in nucleus. Is expressed in several structures, including branchial arch; inner ear; limb; liver; and midgut. Orthologous to human KIN (Kin17 DNA and RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 14.9), liver E14 (RPKM 7.3) and 20 other tissues See more
Orthologs
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Genomic context

See Kin in Genome Data Viewer
Location:
2; 2 A1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10085362..10097512)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10080551..10092701)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene predicted gene, 54137 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 Neighboring gene predicted gene, 23608 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2 Neighboring gene inter-alpha-trypsin inhibitor, heavy chain 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA damage response IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA/RNA-binding protein KIN17
Names
KIN, antigenic determinant of recA protein homolog
antigenic determinant of rec-A protein
binding to curved DNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025280.2NP_079556.1  DNA/RNA-binding protein KIN17

    See identical proteins and their annotated locations for NP_079556.1

    Status: VALIDATED

    Source sequence(s)
    AL772367
    Consensus CDS
    CCDS15676.1
    UniProtKB/Swiss-Prot
    Q8K339, Q9CV58
    Related
    ENSMUSP00000043614.8, ENSMUST00000042512.8
    Conserved Domains (4) summary
    smart00451
    Location:2554
    ZnF_U1; U1-like zinc finger
    cd13155
    Location:337390
    KOW_KIN17; KOW_Kin17 is a RNA-binding motif
    sd00020
    Location:2850
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam10357
    Location:55177
    Kin17_mid; Domain of Kin17 curved DNA-binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    10085362..10097512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497366.4XP_006497429.1  DNA/RNA-binding protein KIN17 isoform X1

    Conserved Domains (3) summary
    cd13155
    Location:284337
    KOW_KIN17; KOW_Kin17 is a RNA-binding motif
    pfam10357
    Location:33124
    Kin17_mid; Domain of Kin17 curved DNA-binding protein
    pfam18131
    Location:221273
    KN17_SH3; KN17 SH3-like C-terminal domain