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Kif5c kinesin family member 5C [ Mus musculus (house mouse) ]

Gene ID: 16574, updated on 11-Apr-2024

Summary

Official Symbol
Kif5cprovided by MGI
Official Full Name
kinesin family member 5Cprovided by MGI
Primary source
MGI:MGI:1098269
See related
Ensembl:ENSMUSG00000026764 AllianceGenome:MGI:1098269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Khc; KINN; NKHC; NKHC2
Summary
Predicted to enable several functions, including ATP hydrolysis activity; apolipoprotein receptor binding activity; and plus-end-directed microtubule motor activity. Involved in mRNA transport. Acts upstream of or within motor neuron axon guidance. Located in several cellular components, including axonal growth cone; ciliary rootlet; and neuronal cell body. Is expressed in several structures, including genitourinary system; nervous system; nose; and retina. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 81.9), cerebellum adult (RPKM 60.5) and 5 other tissues See more
Orthologs
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Genomic context

See Kif5c in Genome Data Viewer
Location:
2 C1.1; 2 28.68 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (49509298..49664790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (49619286..49774778)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49307666-49307775 Neighboring gene predicted gene, 25215 Neighboring gene STARR-positive B cell enhancer ABC_E807 Neighboring gene STARR-seq mESC enhancer starr_04442 Neighboring gene enhancer of polycomb homolog 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:49589986-49590287 Neighboring gene predicted gene, 46738 Neighboring gene STARR-seq mESC enhancer starr_04444 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49672814-49673015 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:49703331-49703484 Neighboring gene LY6/PLAUR domain containing 6B Neighboring gene STARR-seq mESC enhancer starr_04445 Neighboring gene LY6/PLAUR domain containing 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity TAS
Traceable Author Statement
more info
PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in distal axon IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of kinesin complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin heavy chain isoform 5C
Names
kinesin heavy chain member 5C
kinesin heavy chain neuron-specific 2
kinesin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008449.3NP_032475.2  kinesin heavy chain isoform 5C

    See identical proteins and their annotated locations for NP_032475.2

    Status: VALIDATED

    Source sequence(s)
    BC067051, CJ113909
    Consensus CDS
    CCDS16024.1
    UniProtKB/Swiss-Prot
    P28738, Q6NXI9, Q9Z2F8
    UniProtKB/TrEMBL
    Q3TY51
    Related
    ENSMUSP00000028102.8, ENSMUST00000028102.14
    Conserved Domains (4) summary
    smart00129
    Location:8334
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01369
    Location:6327
    KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
    pfam15619
    Location:605798
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl12013
    Location:636817
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    49509298..49664790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)