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Kif5b kinesin family member 5B [ Mus musculus (house mouse) ]

Gene ID: 16573, updated on 8-Jan-2023

Summary

Official Symbol
Kif5bprovided by MGI
Official Full Name
kinesin family member 5Bprovided by MGI
Primary source
MGI:MGI:1098268
See related
Ensembl:ENSMUSG00000006740 AllianceGenome:MGI:1098268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Khc; Khcs; Kns1; Ukhc
Summary
Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission and stress granule disassembly. Acts upstream of or within cellular response to interferon-gamma; cytoplasm organization; and plus-end-directed vesicle transport along microtubule. Located in ciliary rootlet; neuron projection; and phagocytic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (kinesin family member 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 26.1), bladder adult (RPKM 26.1) and 28 other tissues See more
Orthologs
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Genomic context

See Kif5b in Genome Data Viewer
Location:
18 A1; 18 4.46 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6201005..6241524, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6201005..6241524, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 12 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene predicted gene, 18278 Neighboring gene predicted gene, 41664 Neighboring gene ribosomal protein L27, pseudogene 3 Neighboring gene prothymosin alpha pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule lateral binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in anterograde axonal protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in anterograde dendritic transport of neurotransmitter receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in centrosome localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytoplasm organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within microtubule-based process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mitochondrial transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mitochondrion transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within plus-end-directed vesicle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, GABAergic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde neuronal dense core vesicle transport ISO
Inferred from Sequence Orthology
more info
 
involved_in stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle transport along microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of kinesin complex TAS
Traceable Author Statement
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-1 heavy chain
Names
conventional kinesin heavy chain
kinesin heavy chain member 5B, ubiquitous
ubiquitous kinesin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008448.3NP_032474.2  kinesin-1 heavy chain

    See identical proteins and their annotated locations for NP_032474.2

    Status: VALIDATED

    Source sequence(s)
    AC113003, AI788274, AK014590, AV316286, BC090841
    Consensus CDS
    CCDS37724.1
    UniProtKB/Swiss-Prot
    Q61580, Q61768
    UniProtKB/TrEMBL
    A0A8C6HJA0, Q9CUT6
    Related
    ENSMUSP00000025083.8, ENSMUST00000025083.14
    Conserved Domains (5) summary
    smart00129
    Location:8332
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01369
    Location:6325
    KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
    pfam05010
    Location:467662
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07851
    Location:598686
    TMPIT; TMPIT-like protein
    pfam14235
    Location:462538
    DUF4337; Domain of unknown function (DUF4337)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    6201005..6241524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)