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DNAJB8 DnaJ heat shock protein family (Hsp40) member B8 [ Homo sapiens (human) ]

Gene ID: 165721, updated on 1-Jun-2020

Summary

Official Symbol
DNAJB8provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B8provided by HGNC
Primary source
HGNC:HGNC:23699
See related
Ensembl:ENSG00000179407 MIM:611337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ6; CT156
Summary
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
Expression
Restricted expression toward testis (RPKM 16.6) See more
Orthologs

Genomic context

See DNAJB8 in Genome Data Viewer
Location:
3q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (128462434..128467248, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128181275..128186091, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA specific Neighboring gene CRISPRi-validated cis-regulatory element chr3.3679 Neighboring gene CRISPRi-FlowFISH-validated RPN1 regulatory element Neighboring gene DNAJB8 antisense RNA 1 Neighboring gene CRISPRi-FlowFISH-validated H1-10 regulatory element Neighboring gene GATA2 antisense RNA 1 Neighboring gene GATA binding protein 2 Neighboring gene uncharacterized LOC90246

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily B member 8
Names
DnaJ (Hsp40) homolog, subfamily B, member 8
testicular tissue protein Li 56

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153330.5NP_699161.1  dnaJ homolog subfamily B member 8

    See identical proteins and their annotated locations for NP_699161.1

    Status: REVIEWED

    Source sequence(s)
    AC080005, AI188219, BC050288, KF459586
    Consensus CDS
    CCDS3048.1
    UniProtKB/Swiss-Prot
    Q8NHS0
    UniProtKB/TrEMBL
    A0A140VJI2
    Related
    ENSP00000316053.3, ENST00000319153.3
    Conserved Domains (1) summary
    COG0484
    Location:3106
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    128462434..128467248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713519.4XP_006713582.1  dnaJ homolog subfamily B member 8 isoform X1

    See identical proteins and their annotated locations for XP_006713582.1

    UniProtKB/Swiss-Prot
    Q8NHS0
    UniProtKB/TrEMBL
    A0A140VJI2
    Related
    ENSP00000417418.1, ENST00000469083.1
    Conserved Domains (1) summary
    COG0484
    Location:3106
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
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