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DNAJB8 DnaJ heat shock protein family (Hsp40) member B8 [ Homo sapiens (human) ]

Gene ID: 165721, updated on 17-Sep-2024

Summary

Official Symbol
DNAJB8provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B8provided by HGNC
Primary source
HGNC:HGNC:23699
See related
Ensembl:ENSG00000179407 MIM:611337; AllianceGenome:HGNC:23699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ6; CT156
Summary
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
Expression
Restricted expression toward testis (RPKM 16.6) See more
Orthologs
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Genomic context

See DNAJB8 in Genome Data Viewer
Location:
3q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (128462437..128466890, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (131204036..131208509, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128181280..128185733, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128150709-128151289 Neighboring gene uncharacterized LOC124909428 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128151290-128151869 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128151870-128152450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128154435-128155122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20483 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128170962-128171462 Neighboring gene uncharacterized LOC124909429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128177612-128178132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128178133-128178652 Neighboring gene DNAJB8 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128202328-128202892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128202893-128203457 Neighboring gene GATA binding protein 2 Neighboring gene CRISPRi-FlowFISH-validated H1-10 regulatory element 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128208361-128209172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:128209173-128209982 Neighboring gene GATA2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14707 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:128223035-128224234 Neighboring gene uncharacterized LOC90246

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC33884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily B member 8
Names
DnaJ (Hsp40) homolog, subfamily B, member 8
testicular tissue protein Li 56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153330.6NP_699161.1  dnaJ homolog subfamily B member 8

    See identical proteins and their annotated locations for NP_699161.1

    Status: REVIEWED

    Source sequence(s)
    AC080005, KF459586
    Consensus CDS
    CCDS3048.1
    UniProtKB/Swiss-Prot
    B3KWV7, Q8NHS0
    UniProtKB/TrEMBL
    A0A140VJI2
    Related
    ENSP00000316053.3, ENST00000319153.4
    Conserved Domains (1) summary
    COG0484
    Location:3106
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    128462437..128466890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    131204036..131208509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)