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Kif3b kinesin family member 3B [ Mus musculus (house mouse) ]

Gene ID: 16569, updated on 21-Apr-2024

Summary

Official Symbol
Kif3bprovided by MGI
Official Full Name
kinesin family member 3Bprovided by MGI
Primary source
MGI:MGI:107688
See related
Ensembl:ENSMUSG00000027475 AllianceGenome:MGI:107688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0359
Summary
Enables intraciliary transport particle B binding activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex; cilium assembly; and vesicle-mediated transport. Located in centrosome; cilium; and dendrite. Part of kinesin II complex. Is expressed in several structures, including central nervous system; gonad; gut; hemolymphoid system gland; and nose. Used to study schizophrenia. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.3), CNS E18 (RPKM 14.0) and 25 other tissues See more
Orthologs
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Genomic context

Location:
2 H1; 2 75.41 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153132028..153175310)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153291395..153333390)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene pleiomorphic adenoma gene-like 2 Neighboring gene protein O-fucosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7868 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153088886-153089039 Neighboring gene STARR-positive B cell enhancer ABC_E6002 Neighboring gene predicted gene, 39961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:153161910-153162194 Neighboring gene RIKEN cDNA 2500004C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E7869 Neighboring gene STARR-seq mESC enhancer starr_06089 Neighboring gene STARR-positive B cell enhancer ABC_E7870 Neighboring gene ASXL transcriptional regulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intraciliary transport particle B binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anterograde dendritic transport of neurotransmitter receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary transport ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in opsin transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of kinesin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin II complex ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF3B
Names
microtubule plus end-directed kinesin motor 3B
NP_032470.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008444.4NP_032470.3  kinesin-like protein KIF3B

    See identical proteins and their annotated locations for NP_032470.3

    Status: VALIDATED

    Source sequence(s)
    AK147467, BC065132, CJ089315
    Consensus CDS
    CCDS16911.1
    UniProtKB/Swiss-Prot
    Q3UFZ8, Q61771, Q8BNH4
    UniProtKB/TrEMBL
    Q3UHC4, Q80U27
    Related
    ENSMUSP00000028977.7, ENSMUST00000028977.7
    Conserved Domains (2) summary
    cd01371
    Location:8340
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:15340
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    153132028..153175310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_374419.4 RNA Sequence