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PARP15 poly(ADP-ribose) polymerase family member 15 [ Homo sapiens (human) ]

Gene ID: 165631, updated on 25-Jan-2022

Summary

Official Symbol
PARP15provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 15provided by HGNC
Primary source
HGNC:HGNC:26876
See related
Ensembl:ENSG00000173200 MIM:612066; AllianceGenome:HGNC:26876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL3; ARTD7; pART7
Summary
PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al., 2005 [PubMed 16061477]).[supplied by OMIM, May 2008]
Expression
Biased expression in spleen (RPKM 9.7), lymph node (RPKM 8.3) and 8 other tissues See more
Orthologs
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Genomic context

See PARP15 in Genome Data Viewer
Location:
3q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122575926..122639047)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122296497..122357894)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374071 Neighboring gene Sharpr-MPRA regulatory region 13157 Neighboring gene poly(ADP-ribose) polymerase family member 9 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8 Neighboring gene poly(ADP-ribose) polymerase family member 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder.
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40196, FLJ40597, MGC126750, MGC126752

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+ binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein ADP-ribosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein mono-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein mono-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein poly-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP15
Names
ADP-ribosyltransferase diphtheria toxin-like 7
B-aggressive lymphoma 3
B-aggressive lymphoma protein 3
PARP-15
poly [ADP-ribose] polymerase 15
NP_001106995.1
NP_001295249.1
NP_001295250.1
NP_689828.1
XP_005247216.1
XP_005247217.1
XP_011510777.1
XP_011510778.1
XP_011510779.1
XP_011510780.1
XP_011510781.1
XP_011510782.1
XP_016861280.1
XP_016861281.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113523.3NP_001106995.1  protein mono-ADP-ribosyltransferase PARP15 isoform 1

    See identical proteins and their annotated locations for NP_001106995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC092908, AK097916, AK309863, BC101701, BX647656, DQ063586
    Consensus CDS
    CCDS46893.1
    UniProtKB/Swiss-Prot
    Q460N3
    Related
    ENSP00000417214.2, ENST00000464300.7
    Conserved Domains (4) summary
    COG2110
    Location:88260
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd01439
    Location:556676
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:89230
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    pfam00644
    Location:499676
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  2. NM_001308320.2NP_001295249.1  protein mono-ADP-ribosyltransferase PARP15 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate in-frame coding exons and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter compared to isoform 1.
    Source sequence(s)
    AC092908, AK097916, BX647656
    Consensus CDS
    CCDS77803.1
    UniProtKB/Swiss-Prot
    Q460N3
    UniProtKB/TrEMBL
    C9J7L3
    Related
    ENSP00000417785.1, ENST00000483793.5
    Conserved Domains (3) summary
    cd01439
    Location:361481
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:304481
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00019
    Location:181287
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  3. NM_001308321.2NP_001295250.1  protein mono-ADP-ribosyltransferase PARP15 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001295250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, resulting in the presence of a novel 5' coding region and start codon, compared to variant 1. The encoded isoform (4) has a shorter distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC092908, BC143573, BX647656
    Consensus CDS
    CCDS77804.1
    UniProtKB/TrEMBL
    B7ZL48
    Related
    ENSP00000419488.1, ENST00000493645.1
    Conserved Domains (3) summary
    cd01439
    Location:253373
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:196373
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00019
    Location:70179
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  4. NM_152615.3NP_689828.1  protein mono-ADP-ribosyltransferase PARP15 isoform 2 precursor

    See identical proteins and their annotated locations for NP_689828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in the presence of a novel 5' coding region and start codon. The encoded isoform (2) has a shorter distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC092908, AK097916, BC101701, BX647656
    Consensus CDS
    CCDS3016.1
    UniProtKB/Swiss-Prot
    Q460N3
    Related
    ENSP00000308436.4, ENST00000310366.8
    Conserved Domains (2) summary
    cd01439
    Location:322442
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:70197
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    122575926..122639047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512475.3XP_011510777.1  protein mono-ADP-ribosyltransferase PARP15 isoform X1

    Conserved Domains (3) summary
    smart00506
    Location:266382
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:516636
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam01661
    Location:67176
    Macro; Macro domain
  2. XM_005247159.4XP_005247216.1  protein mono-ADP-ribosyltransferase PARP15 isoform X3

    Conserved Domains (2) summary
    smart00506
    Location:90223
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:487607
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  3. XM_011512476.3XP_011510778.1  protein mono-ADP-ribosyltransferase PARP15 isoform X2

    Conserved Domains (2) summary
    smart00506
    Location:90223
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:506626
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  4. XM_005247160.4XP_005247217.1  protein mono-ADP-ribosyltransferase PARP15 isoform X4

    Conserved Domains (3) summary
    smart00506
    Location:230346
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:480600
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl00019
    Location:107179
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  5. XM_017005791.2XP_016861280.1  protein mono-ADP-ribosyltransferase PARP15 isoform X6

    Conserved Domains (3) summary
    smart00506
    Location:230336
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:411531
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl00019
    Location:107179
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  6. XM_011512477.3XP_011510779.1  protein mono-ADP-ribosyltransferase PARP15 isoform X5

    Conserved Domains (3) summary
    smart00506
    Location:181296
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:430550
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cl00019
    Location:107179
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  7. XM_011512480.3XP_011510782.1  protein mono-ADP-ribosyltransferase PARP15 isoform X8

    Conserved Domains (2) summary
    smart00506
    Location:90223
    A1pp; Appr-1"-p processing enzyme
    cl00019
    Location:306350
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  8. XM_011512478.3XP_011510780.1  protein mono-ADP-ribosyltransferase PARP15 isoform X7

    See identical proteins and their annotated locations for XP_011510780.1

    Conserved Domains (2) summary
    smart00506
    Location:53169
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:303423
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  9. XM_011512479.3XP_011510781.1  protein mono-ADP-ribosyltransferase PARP15 isoform X7

    See identical proteins and their annotated locations for XP_011510781.1

    Conserved Domains (2) summary
    smart00506
    Location:53169
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:303423
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  10. XM_017005792.2XP_016861281.1  protein mono-ADP-ribosyltransferase PARP15 isoform X7

    Conserved Domains (2) summary
    smart00506
    Location:53169
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:303423
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
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