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Kif17 kinesin family member 17 [ Mus musculus (house mouse) ]

Gene ID: 16559, updated on 5-Jan-2023

Summary

Official Symbol
Kif17provided by MGI
Official Full Name
kinesin family member 17provided by MGI
Primary source
MGI:MGI:1098229
See related
Ensembl:ENSMUSG00000028758 AllianceGenome:MGI:1098229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kif17b; mKIAA1405; 5930435E01Rik
Summary
Enables microtubule motor activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex. Acts upstream of or within microtubule-based process; protein-containing complex localization; and vesicle-mediated transport. Located in cytoskeleton; periciliary membrane compartment; and photoreceptor connecting cilium. Part of intraciliary transport particle B and kinesin complex. Is expressed in central nervous system; retina; and testis. Orthologous to human KIF17 (kinesin family member 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 90.7) and cortex adult (RPKM 5.4) See more
Orthologs
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Genomic context

See Kif17 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137989562..138029284)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138262251..138301973)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene heterochromatin protein 1, binding protein 3 Neighboring gene SH2 domain containing 5 Neighboring gene predicted gene, 54278 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase Neighboring gene microRNA 7019 Neighboring gene PTEN induced putative kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Sh2d5

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of kinesin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF17
Names
N-4 kinesin
kinesin 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190978.1NP_001177907.1  kinesin-like protein KIF17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks both an in-frame segment in the central coding region and an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK077868, AK083171, AL807249, BI133873
    Consensus CDS
    CCDS57307.1
    UniProtKB/TrEMBL
    A2AM72
    Related
    ENSMUSP00000101447.3, ENSMUST00000105821.3
    Conserved Domains (2) summary
    cl22853
    Location:4335
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:11335
    Kinesin; Kinesin motor domain
  2. NM_010623.4NP_034753.1  kinesin-like protein KIF17 isoform 1

    See identical proteins and their annotated locations for NP_034753.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL807249
    Consensus CDS
    CCDS18823.1
    UniProtKB/Swiss-Prot
    A2AM73, Q99PW8
    Related
    ENSMUSP00000030539.4, ENSMUST00000030539.10
    Conserved Domains (3) summary
    cl22853
    Location:4335
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:11335
    Kinesin; Kinesin motor domain
    pfam16214
    Location:9181036
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    137989562..138029284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)