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Kif12 kinesin family member 12 [ Mus musculus (house mouse) ]

Gene ID: 16552, updated on 26-Sep-2022

Summary

Official Symbol
Kif12provided by MGI
Official Full Name
kinesin family member 12provided by MGI
Primary source
MGI:MGI:1098232
See related
Ensembl:ENSMUSG00000028357 AllianceGenome:MGI:1098232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in microtubule organizing center. Is expressed in embryo and inner cell mass. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 61.1), colon adult (RPKM 9.6) and 1 other tissue See more
Orthologs
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Genomic context

See Kif12 in Genome Data Viewer
Location:
4; 4 B3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63076185..63090382, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63157948..63172145, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 618 Neighboring gene predicted gene, 30764 Neighboring gene alpha 1 microglobulin/bikunin precursor Neighboring gene collagen, type XXVII, alpha 1 Neighboring gene microRNA 455 Neighboring gene predicted gene, 52743

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
kinesin-like protein KIF12
Names
N-9 kinesin
kinesin 12
kinesin superfamily protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317352.1NP_001304281.1  kinesin-like protein KIF12 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL691496
    Consensus CDS
    CCDS89761.1
    UniProtKB/TrEMBL
    A0A1Y7VK29
    Related
    ENSMUSP00000152690.2, ENSMUST00000156618.9
    Conserved Domains (3) summary
    cd00106
    Location:25358
    KISc; Kinesin motor domain
    pfam00225
    Location:31360
    Kinesin; Kinesin motor domain
    pfam12711
    Location:379464
    Kinesin-relat_1; Kinesin motor
  2. NM_010616.3NP_034746.1  kinesin-like protein KIF12 isoform 2

    See identical proteins and their annotated locations for NP_034746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK018598, BP765257
    Consensus CDS
    CCDS18249.1
    UniProtKB/Swiss-Prot
    O35061, Q9D2Z8
    Related
    ENSMUSP00000030042.3, ENSMUST00000030042.3
    Conserved Domains (3) summary
    cd00106
    Location:25358
    KISc; Kinesin motor domain
    pfam00225
    Location:31360
    Kinesin; Kinesin motor domain
    pfam12711
    Location:379464
    Kinesin-relat_1; Kinesin motor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63076185..63090382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319998.3XP_017175487.1  kinesin-like protein KIF12 isoform X1

    Conserved Domains (1) summary
    cd00106
    Location:25358
    KISc; Kinesin motor domain
  2. XM_017319999.3XP_017175488.1  kinesin-like protein KIF12 isoform X2

    Conserved Domains (1) summary
    cd00106
    Location:25358
    KISc; Kinesin motor domain
  3. XM_017320000.2XP_017175489.1  kinesin-like protein KIF12 isoform X3

    Conserved Domains (1) summary
    cd00106
    Location:25358
    KISc; Kinesin motor domain