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Kera keratocan [ Mus musculus (house mouse) ]

Gene ID: 16545, updated on 27-Nov-2024

Summary

Official Symbol
Keraprovided by MGI
Official Full Name
keratocanprovided by MGI
Primary source
MGI:MGI:1202398
See related
Ensembl:ENSMUSG00000019932 AllianceGenome:MGI:1202398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KTN; CNA2; SLRR2B
Summary
Acts upstream of or within cornea development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; connective tissue; jaw; limb; and sensory organ. Used to study cornea plana. Human ortholog(s) of this gene implicated in arcus senilis; cornea plana; and corneal dystrophy. Orthologous to human KERA (keratocan). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward limb E14.5 (RPKM 43.4) See more
Orthologs
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Genomic context

See Kera in Genome Data Viewer
Location:
10 C3; 10 50.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (97442873..97449555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (97606962..97613688)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930473O22 gene Neighboring gene lumican Neighboring gene predicted gene, 40749 Neighboring gene epiphycan Neighboring gene predicted gene 10754

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General protein information

Preferred Names
keratocan
Names
keratan sulfate proteoglycan keratocan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008438.3NP_032464.1  keratocan precursor

    See identical proteins and their annotated locations for NP_032464.1

    Status: VALIDATED

    Source sequence(s)
    AC159710
    Consensus CDS
    CCDS36044.1
    UniProtKB/Swiss-Prot
    O35367
    UniProtKB/TrEMBL
    A4FUJ3, Q8C3D9
    Related
    ENSMUSP00000100923.3, ENSMUST00000105286.4
    Conserved Domains (3) summary
    PRK15370
    Location:16298
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:7497
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:268331
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    97442873..97449555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513273.5XP_006513336.1  keratocan isoform X1

    See identical proteins and their annotated locations for XP_006513336.1

    UniProtKB/Swiss-Prot
    O35367
    UniProtKB/TrEMBL
    A4FUJ3, Q8C3D9
    Conserved Domains (3) summary
    PRK15370
    Location:16298
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:7497
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:268331
    LRR_8; Leucine rich repeat