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Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16536, updated on 14-Mar-2023

Summary

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Official Symbol
Kcnq2provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 2provided by MGI
Primary source
MGI:MGI:1309503
See related
Ensembl:ENSMUSG00000016346 AllianceGenome:MGI:1309503
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KQT2; HNSPC; Nmf134
Summary
Enables calmodulin binding activity and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and transmission of nerve impulse. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including brain; gut; immune system; reproductive system; and white fat. Used to study benign neonatal seizures and developmental and epileptic encephalopathy 7. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 26.0), frontal lobe adult (RPKM 26.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnq2 in Genome Data Viewer
Location:
2 H4; 2 103.57 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180717372..180777368, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181075579..181135580, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene collagen, type XX, alpha 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene predicted gene, 24892

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation. Tian F, et al. Neurobiol Dis, 2022 Nov. PMID 36113748
  2. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior. Tsuboi D, et al. Cell Rep, 2022 Sep 6. PMID 36070693
  3. Mouse models of Kcnq2 dysfunction. Brun L, et al. Epilepsia, 2022 Nov. PMID 36047730, Free PMC Article
  4. Heterozygous Deletion of Epilepsy Gene KCNQ2 Has Negligible Effects on Learning and Memory. Tracy GC, et al. Front Behav Neurosci, 2022. PMID 35928789, Free PMC Article
  5. Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy. Biba-Maazou N, et al. J Physiol, 2022 May. PMID 35389519

See all (89) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse models of Kcnq2 dysfunction.
    Title: Mouse models of Kcnq2 dysfunction.
  2. Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation.
    Title: Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation.
  3. Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
    Title: Genetic interaction between Scn8a and potassium channel genes Kcna1 and Kcnq2.
  4. Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior.
    Title: Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior.
  5. Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy.
    Title: Time-limited alterations in cortical activity of a knock-in mouse model of KCNQ2-related developmental and epileptic encephalopathy.
  6. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
    Title: KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
  7. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.
    Title: Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension.
  8. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning.
    Title: Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning.
  9. Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of Kv7.2.
    Title: Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of K(v)7.2.
  10. Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family.
    Title: Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon initial segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in node of Ranvier IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily KQT member 2
Names
KQT-like 2
potassium channel subunit alpha KvLQT2
voltage-gated potassium channel subunit Kv7.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003824.2 → NP_001003824.1  potassium voltage-gated channel subfamily KQT member 2 isoform 2

    See identical proteins and their annotated locations for NP_001003824.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons but includes an additional in-frame exon, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450341, BC145453, CJ121810, CJ263767
    Consensus CDS
    CCDS17193.1
    UniProtKB/TrEMBL
    B7ZBV4
    Related
    ENSMUSP00000016491.8, ENSMUST00000016491.14
    Conserved Domains (4) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:444 → 666
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel
    pfam16642
    Location:675 → 754
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  2. NM_001003825.3 → NP_001003825.1  potassium voltage-gated channel subfamily KQT member 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice site, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450341, CJ119072, CJ121810, CJ263767
    Consensus CDS
    CCDS17194.1
    UniProtKB/TrEMBL
    B7ZBV6
    Related
    ENSMUSP00000052453.9, ENSMUST00000049792.15
    Conserved Domains (4) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:444 → 661
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel
    pfam16642
    Location:670 → 749
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  3. NM_001006668.2 → NP_001006669.1  potassium voltage-gated channel subfamily KQT member 2 isoform 4

    See identical proteins and their annotated locations for NP_001006669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons but includes an additional in-frame exon, it uses an alternate in-frame splice site, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450341, CJ119072, CJ121810, CJ263767
    Consensus CDS
    CCDS17195.1
    UniProtKB/TrEMBL
    B7ZBV8
    Related
    ENSMUSP00000099336.4, ENSMUST00000103047.10
    Conserved Domains (4) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:432 → 654
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel
    pfam16642
    Location:663 → 742
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  4. NM_001006669.2 → NP_001006670.1  potassium voltage-gated channel subfamily KQT member 2 isoform 5

    See identical proteins and their annotated locations for NP_001006670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450341, CJ119072, CJ121810, CJ263767
    Consensus CDS
    CCDS17196.1
    UniProtKB/TrEMBL
    A0A8C6H634, B7ZBV7
    Related
    ENSMUSP00000099337.4, ENSMUST00000103048.10
    Conserved Domains (4) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:444 → 630
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel
    pfam16642
    Location:639 → 718
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  5. NM_001006674.2 → NP_001006675.1  potassium voltage-gated channel subfamily KQT member 2 isoform 6

    See identical proteins and their annotated locations for NP_001006675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons, and it also contains alternate 3' exon structure resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL450341, CJ119072, CJ121810, CJ263767
    Consensus CDS
    CCDS17197.1
    UniProtKB/Swiss-Prot
    Q9Z351
    UniProtKB/TrEMBL
    A0A8C6H7U3, B7ZBV5
    Related
    ENSMUSP00000080243.7, ENSMUST00000081528.13
    Conserved Domains (3) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:444 → 561
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel

  6. NM_001302888.1 → NP_001289817.1  potassium voltage-gated channel subfamily KQT member 2 isoform 13

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) lacks an alternate in-frame exon and uses an alternate in-frame splice site, resulting in an isoform (13) that is shorter than isoform 1.
    Source sequence(s)
    AK139411, AL450341, CJ119072, CJ121810, CJ263767
    UniProtKB/Swiss-Prot
    Q9Z351
    Related
    ENSMUSP00000099338.4, ENSMUST00000103049.10
    Conserved Domains (5) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:454 → 639
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel
    pfam11956
    Location:757 → 847
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:648 → 735
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  7. NM_010611.3 → NP_034741.2  potassium voltage-gated channel subfamily KQT member 2 isoform 1

    See identical proteins and their annotated locations for NP_034741.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK135059, AK139411, AL450341, CJ119072, CJ121810, CJ125938, CJ263767
    Consensus CDS
    CCDS17198.1
    UniProtKB/Swiss-Prot
    Q9Z351
    UniProtKB/TrEMBL
    B7ZBV9, Q3UY10
    Related
    ENSMUSP00000122915.3, ENSMUST00000149964.9
    Conserved Domains (5) summary
    pfam00520
    Location:119 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:472 → 658
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:240 → 314
    Ion_trans_2; Ion channel
    pfam11956
    Location:776 → 866
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:667 → 754
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180717372..180777368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315767.3 → XP_017171256.1  potassium voltage-gated channel subfamily KQT member 2 isoform X24

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:426 → 612
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:733 → 826
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:627 → 714
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  2. XM_017315754.3 → XP_017171243.1  potassium voltage-gated channel subfamily KQT member 2 isoform X17

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:426 → 648
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:769 → 862
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:663 → 750
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  3. XM_030247788.2 → XP_030103648.1  potassium voltage-gated channel subfamily KQT member 2 isoform X21

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:438 → 623
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:744 → 837
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:638 → 725
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  4. XM_030247775.2 → XP_030103635.1  potassium voltage-gated channel subfamily KQT member 2 isoform X9

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:438 → 690
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:811 → 904
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:705 → 792
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  5. XM_006500567.3 → XP_006500630.1  potassium voltage-gated channel subfamily KQT member 2 isoform X20

    UniProtKB/TrEMBL
    A0A0G2JFQ2
    Related
    ENSMUSP00000143263.2, ENSMUST00000197015.5
    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:438 → 624
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:745 → 838
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:639 → 726
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  6. XM_017315747.3 → XP_017171236.1  potassium voltage-gated channel subfamily KQT member 2 isoform X14

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:438 → 660
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:781 → 874
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:675 → 762
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  7. XM_017315751.3 → XP_017171240.1  potassium voltage-gated channel subfamily KQT member 2 isoform X15

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:438 → 655
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:776 → 869
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:670 → 757
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  8. XM_017315743.3 → XP_017171232.1  potassium voltage-gated channel subfamily KQT member 2 isoform X8

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:438 → 691
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:812 → 905
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:706 → 793
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  9. XM_036158776.1 → XP_036014669.1  potassium voltage-gated channel subfamily KQT member 2 isoform X18

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:456 → 641
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:755 → 855
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:656 → 743
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  10. XM_030247769.2 → XP_030103629.1  potassium voltage-gated channel subfamily KQT member 2 isoform X4

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:456 → 708
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:829 → 922
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:723 → 810
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  11. XM_017315740.3 → XP_017171229.1  potassium voltage-gated channel subfamily KQT member 2 isoform X3

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:456 → 709
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:830 → 923
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:724 → 811
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  12. XM_006500568.3 → XP_006500631.1  potassium voltage-gated channel subfamily KQT member 2 isoform X23

    UniProtKB/TrEMBL
    B7ZBW2
    Related
    ENSMUSP00000099339.5, ENSMUST00000103050.10
    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:436 → 621
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:742 → 835
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:636 → 723
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  13. XM_017315763.3 → XP_017171252.1  potassium voltage-gated channel subfamily KQT member 2 isoform X22

    Related
    ENSMUSP00000123488.2, ENSMUST00000129695.8
    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:436 → 622
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:743 → 836
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:637 → 724
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  14. XM_017315744.3 → XP_017171233.1  potassium voltage-gated channel subfamily KQT member 2 isoform X10

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:436 → 689
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:810 → 903
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:704 → 791
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  15. XM_030247772.2 → XP_030103632.1  potassium voltage-gated channel subfamily KQT member 2 isoform X7

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:448 → 700
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:821 → 914
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:715 → 802
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  16. XM_006500565.3 → XP_006500628.1  potassium voltage-gated channel subfamily KQT member 2 isoform X19

    UniProtKB/TrEMBL
    B7ZBW1
    Related
    ENSMUSP00000099340.3, ENSMUST00000103051.9
    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:448 → 634
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:755 → 848
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:649 → 736
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  17. XM_036158772.1 → XP_036014665.1  potassium voltage-gated channel subfamily KQT member 2 isoform X13

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:448 → 670
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:784 → 884
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:685 → 772
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  18. XM_017315742.3 → XP_017171231.1  potassium voltage-gated channel subfamily KQT member 2 isoform X6

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:448 → 701
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:822 → 915
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:716 → 803
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  19. XM_017315741.3 → XP_017171230.1  potassium voltage-gated channel subfamily KQT member 2 isoform X5

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:454 → 707
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:828 → 921
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:722 → 809
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  20. XM_017315753.3 → XP_017171242.1  potassium voltage-gated channel subfamily KQT member 2 isoform X16

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:466 → 651
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:772 → 865
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:666 → 753
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  21. XM_017315738.3 → XP_017171227.1  potassium voltage-gated channel subfamily KQT member 2 isoform X2

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:466 → 718
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:839 → 932
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:733 → 820
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  22. XM_011239925.3 → XP_011238227.1  potassium voltage-gated channel subfamily KQT member 2 isoform X11

    UniProtKB/TrEMBL
    A0A8C6H660
    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:466 → 688
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:809 → 902
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:703 → 790
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  23. XM_017315746.3 → XP_017171235.1  potassium voltage-gated channel subfamily KQT member 2 isoform X12

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:466 → 683
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:804 → 897
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:698 → 785
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  24. XM_017315735.3 → XP_017171224.1  potassium voltage-gated channel subfamily KQT member 2 isoform X1

    Conserved Domains (4) summary
    pfam00520
    Location:92 → 324
    Ion_trans; Ion transport protein
    pfam03520
    Location:466 → 719
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:840 → 933
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:734 → 821
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  25. XM_030247798.2 → XP_030103658.1  potassium voltage-gated channel subfamily KQT member 2 isoform X26

    Conserved Domains (4) summary
    pfam00520
    Location:1 → 151
    Ion_trans; Ion transport protein
    pfam03520
    Location:265 → 518
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:639 → 732
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:533 → 620
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  26. XM_036158780.1 → XP_036014673.1  potassium voltage-gated channel subfamily KQT member 2 isoform X27

    Conserved Domains (3) summary
    pfam03520
    Location:17 → 270
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:384 → 484
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:285 → 372
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  27. XM_030247797.1 → XP_030103657.1  potassium voltage-gated channel subfamily KQT member 2 isoform X25

    Conserved Domains (4) summary
    pfam00520
    Location:1 → 151
    Ion_trans; Ion transport protein
    pfam03520
    Location:293 → 546
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:667 → 760
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:561 → 648
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  28. XM_017315771.3 → XP_017171260.1  potassium voltage-gated channel subfamily KQT member 2 isoform X27

    Conserved Domains (3) summary
    pfam03520
    Location:17 → 270
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:384 → 484
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:285 → 372
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  29. XM_017315781.3 → XP_017171270.1  potassium voltage-gated channel subfamily KQT member 2 isoform X28

    Conserved Domains (3) summary
    pfam03520
    Location:17 → 269
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:390 → 483
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:284 → 371
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  30. XM_017315772.3 → XP_017171261.1  potassium voltage-gated channel subfamily KQT member 2 isoform X27

    Conserved Domains (3) summary
    pfam03520
    Location:17 → 270
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:384 → 484
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:285 → 372
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  31. XM_017315776.3 → XP_017171265.1  potassium voltage-gated channel subfamily KQT member 2 isoform X27

    Conserved Domains (3) summary
    pfam03520
    Location:17 → 270
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:384 → 484
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:285 → 372
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

  32. XM_017315773.3 → XP_017171262.1  potassium voltage-gated channel subfamily KQT member 2 isoform X27

    Conserved Domains (3) summary
    pfam03520
    Location:17 → 270
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:384 → 484
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3
    pfam16642
    Location:285 → 372
    KCNQ2_u3; Unstructured region on Potassium channel subunit alpha KvLQT2

RNA

  1. XR_003950848.2 RNA Sequence

  2. XR_004938437.1 RNA Sequence

  3. XR_004938426.1 RNA Sequence

  4. XR_004938432.1 RNA Sequence

  5. XR_001781086.3 RNA Sequence

  6. XR_001781085.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006675.1: Suppressed sequence

    Description
    NM_001006675.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.

  2. NM_001006676.1: Suppressed sequence

    Description
    NM_001006676.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.

  3. NM_001006677.1: Suppressed sequence

    Description
    NM_001006677.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.

  4. NM_001006678.1: Suppressed sequence

    Description
    NM_001006678.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears incomplete at the 3' end.

  5. NM_001006679.1: Suppressed sequence

    Description
    NM_001006679.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.

  6. NM_001006680.1: Suppressed sequence

    Description
    NM_001006680.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain intronic sequence at its 3' end.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z351.1 GenPept UniProtKB/Swiss-Prot:Q9Z351

Gene LinkOut

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