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Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16535, updated on 19-Sep-2024

Summary

Official Symbol
Kcnq1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 1provided by MGI
Primary source
MGI:MGI:108083
See related
Ensembl:ENSMUSG00000009545 AllianceGenome:MGI:108083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kcna9; KVLQT1
Summary
Enables voltage-gated potassium channel activity. Involved in several processes, including animal organ development; inorganic ion homeostasis; and regulation of heart contraction. Acts upstream of or within circulatory system development; negative regulation of gene expression; and regulation of gene expression by genetic imprinting. Located in apical part of cell; neuron projection; and transport vesicle. Part of voltage-gated potassium channel complex. Is active in several cellular components, including apical plasma membrane; basolateral part of cell; and ciliary base. Is expressed in several structures, including alimentary system; extraembryonic component; heart; hemolymphoid system gland; and reproductive system. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome 1. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 20.0), colon adult (RPKM 19.5) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnq1 in Genome Data Viewer
Location:
7 F5; 7 88.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142660614..142980787)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143106877..143427050)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CD81 antigen Neighboring gene tumor-suppressing subchromosomal transferable fragment 4 Neighboring gene transient receptor potential cation channel, subfamily M, member 5 Neighboring gene VISTA enhancer mm183 Neighboring gene STARR-seq mESC enhancer starr_20525 Neighboring gene predicted gene 28821 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene STARR-positive B cell enhancer ABC_E10485 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene STARR-seq mESC enhancer starr_20528 Neighboring gene STARR-seq mESC enhancer starr_20529 Neighboring gene STARR-seq mESC enhancer starr_20530 Neighboring gene predicted gene, 33663 Neighboring gene cyclin dependent kinase inhibitor 1C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A catalytic subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 1 binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adrenergic receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell contraction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epinephrine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in corticosterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gastrin-induced gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular chloride ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in iodide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane repolarization during action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane repolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during atrial cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during cardiac muscle cell action potential NAS
Non-traceable Author Statement
more info
PubMed 
involved_in membrane repolarization during ventricular cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within membrane repolarization during ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane repolarization during ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in non-motile cilium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion export across plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
involved_in potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of atrial cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gastric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell membrane repolarization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of voltage-gated sodium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal sodium ion absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to anesthetic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhythmic behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stomach development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in basolateral part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lumenal side of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in neuron projection IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
is_active_in transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily KQT member 1
Names
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
KQT-like 1
voltage-gated potassium channel subunit Kv7.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412611.1NP_001399540.1  potassium voltage-gated channel subfamily KQT member 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012540, AC015800, AC023248
  2. NM_001412612.1NP_001399541.1  potassium voltage-gated channel subfamily KQT member 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012540, AC015800, AC023248
  3. NM_008434.3NP_032460.2  potassium voltage-gated channel subfamily KQT member 1 isoform 1

    See identical proteins and their annotated locations for NP_032460.2

    Status: VALIDATED

    Source sequence(s)
    AC012540, AC015800, AC023248
    Consensus CDS
    CCDS22039.1
    UniProtKB/Swiss-Prot
    O88702, P97414, Q3U4H1, Q7TNZ1, Q7TPL7, Q80VR7
    Related
    ENSMUSP00000009689.5, ENSMUST00000009689.11
    Conserved Domains (3) summary
    pfam00520
    Location:152358
    Ion_trans; Ion transport protein
    pfam03520
    Location:510616
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:269348
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142660614..142980787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508492.3XP_006508555.1  potassium voltage-gated channel subfamily KQT member 1 isoform X6

    Conserved Domains (2) summary
    pfam00520
    Location:12246
    Ion_trans; Ion transport protein
    pfam03520
    Location:398504
    KCNQ_channel; KCNQ voltage-gated potassium channel
  2. XM_006508490.4XP_006508553.3  potassium voltage-gated channel subfamily KQT member 1 isoform X4

    Conserved Domains (2) summary
    PRK12323
    Location:2144
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam00520
    Location:176412
    Ion_trans; Ion transport protein
  3. XM_006508491.4XP_006508554.3  potassium voltage-gated channel subfamily KQT member 1 isoform X5

    Conserved Domains (2) summary
    PRK12323
    Location:2144
    PRK12323; DNA polymerase III subunit gamma/tau
    pfam00520
    Location:176412
    Ion_trans; Ion transport protein
  4. XM_006508488.4XP_006508551.2  potassium voltage-gated channel subfamily KQT member 1 isoform X1

    Conserved Domains (2) summary
    pfam00520
    Location:149378
    Ion_trans; Ion transport protein
    pfam03520
    Location:530636
    KCNQ_channel; KCNQ voltage-gated potassium channel
  5. XM_011241982.3XP_011240284.2  potassium voltage-gated channel subfamily KQT member 1 isoform X2

    Conserved Domains (2) summary
    pfam00520
    Location:149378
    Ion_trans; Ion transport protein
    pfam03520
    Location:530605
    KCNQ_channel; KCNQ voltage-gated potassium channel
  6. XM_006508489.5XP_006508552.2  potassium voltage-gated channel subfamily KQT member 1 isoform X3

    UniProtKB/TrEMBL
    A0A087WNY7
    Related
    ENSMUSP00000139548.2, ENSMUST00000185383.2
    Conserved Domains (1) summary
    pfam00520
    Location:149378
    Ion_trans; Ion transport protein
  7. XM_036152718.1XP_036008611.1  potassium voltage-gated channel subfamily KQT member 1 isoform X7

    Conserved Domains (2) summary
    pfam00520
    Location:27226
    Ion_trans; Ion transport protein
    pfam03520
    Location:378484
    KCNQ_channel; KCNQ voltage-gated potassium channel