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Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [ Mus musculus (house mouse) ]

Gene ID: 16531, updated on 16-Apr-2024

Summary

Official Symbol
Kcnma1provided by MGI
Official Full Name
potassium large conductance calcium-activated channel, subfamily M, alpha member 1provided by MGI
Primary source
MGI:MGI:99923
See related
Ensembl:ENSMUSG00000063142 AllianceGenome:MGI:99923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slo; BKCa; Slo1; mSlo; MaxiK; mSlo1; KCa1.1; slo-alpha; BKCA alpha; k(VCA)alpha; 5730414M22Rik
Summary
Enables identical protein binding activity; large conductance calcium-activated potassium channel activity; and voltage-gated potassium channel activity. Acts upstream of or within several processes, including adult walking behavior; eye blink reflex; and locomotor rhythm. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and postsynaptic membrane. Is integral component of membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 10.4), frontal lobe adult (RPKM 9.3) and 12 other tissues See more
Orthologs
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Genomic context

See Kcnma1 in Genome Data Viewer
Location:
14 A3; 14 12.92 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (23342356..24055173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (23292288..24005110, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene predicted gene, 30783 Neighboring gene predicted gene, 53835 Neighboring gene STARR-seq mESC enhancer starr_36168 Neighboring gene STARR-seq mESC enhancer starr_36169 Neighboring gene predicted gene 10248 Neighboring gene STARR-seq mESC enhancer starr_36171 Neighboring gene STARR-seq mESC enhancer starr_36172 Neighboring gene STARR-seq mESC enhancer starr_36173 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene VISTA enhancer mm417 Neighboring gene STARR-seq mESC enhancer starr_36174 Neighboring gene predicted gene, 53837 Neighboring gene RIKEN cDNA 4930519K11 gene Neighboring gene predicted gene, 46444 Neighboring gene predicted gene, 31392 Neighboring gene predicted gene 6158

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-activated potassium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-activated potassium channel activity TAS
Traceable Author Statement
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables large conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables large conductance calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables large conductance calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables large conductance calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within columnar/cuboidal epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eye blink reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within micturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in micturition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell volume ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of small intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of aldosterone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within relaxation of vascular associated smooth muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to carbon monoxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within saliva secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle contraction involved in micturition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle contraction involved in micturition ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IC
Inferred by Curator
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium-activated potassium channel subunit alpha-1
Names
BK channel alpha subunit
calcium-activated potassium channel, subfamily M subunit alpha-1
maxi K channel
slo homolog
slowpoke homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253358.1NP_001240287.1  calcium-activated potassium channel subunit alpha-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001253359.1NP_001240288.1  calcium-activated potassium channel subunit alpha-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal single aa, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001253360.1NP_001240289.1  calcium-activated potassium channel subunit alpha-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment and an internal single aa, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A087WSJ2, E3VRY9
    Related
    ENSMUSP00000141069.3, ENSMUST00000188210.8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001253361.1NP_001240290.1  calcium-activated potassium channel subunit alpha-1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YCZ9
    Related
    ENSMUSP00000153214.2, ENSMUST00000224077.2
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_001253362.1NP_001240291.1  calcium-activated potassium channel subunit alpha-1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YDC1
    Related
    ENSMUSP00000153362.2, ENSMUST00000223655.2
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001253363.1NP_001240292.1  calcium-activated potassium channel subunit alpha-1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK135652, BC065068
    Consensus CDS
    CCDS79278.1
    UniProtKB/TrEMBL
    A0A087WQN5, A0A286YCW3
    Related
    ENSMUSP00000140275.2, ENSMUST00000188285.7
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. NM_001253364.1NP_001240293.1  calcium-activated potassium channel subunit alpha-1 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (7) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YD59
    Related
    ENSMUSP00000153291.2, ENSMUST00000224232.2
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. NM_001253365.1NP_001240294.1  calcium-activated potassium channel subunit alpha-1 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (9) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK135652, BC065068, L16912
    UniProtKB/TrEMBL
    E3VRY8
    Related
    ENSMUSP00000153078.2, ENSMUST00000224025.2
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. NM_001253366.1NP_001240295.1  calcium-activated potassium channel subunit alpha-1 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (10) lacks an internal segment and an internal single aa, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    E3VRY8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. NM_001253367.1NP_001240296.1  calcium-activated potassium channel subunit alpha-1 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks an in-frame exon and has an alternate splice site in the 3' coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (11) lacks an internal segment and an internal single aa, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YE30
    Related
    ENSMUSP00000153670.2, ENSMUST00000225431.2
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  11. NM_001253368.1NP_001240297.1  calcium-activated potassium channel subunit alpha-1 isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YDR7
    Related
    ENSMUSP00000153527.2, ENSMUST00000224812.2
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. NM_001253369.1NP_001240298.1  calcium-activated potassium channel subunit alpha-1 isoform 13

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (13) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK135652, BC065068, U09383
    Consensus CDS
    CCDS79277.1
    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    UniProtKB/TrEMBL
    A0A286YD35
    Related
    ENSMUSP00000153247.2, ENSMUST00000145596.3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  13. NM_001253370.1NP_001240299.1  calcium-activated potassium channel subunit alpha-1 isoform 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (14) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YCQ2
    Related
    ENSMUSP00000153083.2, ENSMUST00000225471.2
    Conserved Domains (2) summary
    PLN03192
    Location:217393
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK10537
    Location:343415
    PRK10537; voltage-gated potassium channel protein
  14. NM_001253371.1NP_001240300.1  calcium-activated potassium channel subunit alpha-1 isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) lacks an exon and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    E3VRY4
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  15. NM_001253372.1NP_001240301.1  calcium-activated potassium channel subunit alpha-1 isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    Related
    ENSMUSP00000153584.2, ENSMUST00000225315.2
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  16. NM_001253373.1NP_001240302.1  calcium-activated potassium channel subunit alpha-1 isoform 17

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YCF5
    Related
    ENSMUSP00000152959.2, ENSMUST00000225556.2
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:532581
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  17. NM_001253374.1NP_001240303.1  calcium-activated potassium channel subunit alpha-1 isoform 18

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (18) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YCI9
    Related
    ENSMUSP00000152999.2, ENSMUST00000224787.2
    Conserved Domains (3) summary
    pfam00520
    Location:128342
    Ion_trans; Ion transport protein
    pfam03493
    Location:491579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:356469
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  18. NM_001253375.1NP_001240304.1  calcium-activated potassium channel subunit alpha-1 isoform 19

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (19) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    E3VRY6
    Related
    ENSMUSP00000153316.2, ENSMUST00000224285.2
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  19. NM_001253376.1NP_001240305.1  calcium-activated potassium channel subunit alpha-1 isoform 20

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (20) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    E3VRZ4
    Related
    ENSMUSP00000153216.2, ENSMUST00000223749.2
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  20. NM_001253377.1NP_001240306.1  calcium-activated potassium channel subunit alpha-1 isoform 21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) lacks three coding exons, one of which results in a frameshift, compared to variant 1. The resulting isoform (21) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    Consensus CDS
    CCDS79275.1
    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    UniProtKB/TrEMBL
    A0A087WQ41
    Related
    ENSMUSP00000140033.2, ENSMUST00000190044.7
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:538633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:446523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  21. NM_001253378.1NP_001240307.1  calcium-activated potassium channel subunit alpha-1 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) lacks three coding exons and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (22) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154420, AC154433, AC154795, CT010582, CT025624
    UniProtKB/TrEMBL
    A0A286YCW3
    Related
    ENSMUSP00000153158.2, ENSMUST00000223727.2
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  22. NM_010610.3NP_034740.2  calcium-activated potassium channel subunit alpha-1 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF156674, AK135652, BC065068
    Consensus CDS
    CCDS79276.1
    UniProtKB/TrEMBL
    A0A087WRS4, A0A286YDC1
    Related
    ENSMUSP00000140751.2, ENSMUST00000188991.7
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    23342356..24055173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315875.3XP_017171364.1  calcium-activated potassium channel subunit alpha-1 isoform X18

    UniProtKB/TrEMBL
    A0A286YE30
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_017315873.3XP_017171362.1  calcium-activated potassium channel subunit alpha-1 isoform X13

    UniProtKB/TrEMBL
    A0A087WSJ2, E3VRY9
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_006518594.5XP_006518657.1  calcium-activated potassium channel subunit alpha-1 isoform X4

    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_036158482.1XP_036014375.1  calcium-activated potassium channel subunit alpha-1 isoform X17

    UniProtKB/TrEMBL
    A0A286YE30
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:538633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:446523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_036158481.1XP_036014374.1  calcium-activated potassium channel subunit alpha-1 isoform X12

    UniProtKB/TrEMBL
    A0A087WSJ2, E3VRY9
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:538633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:446523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_017315872.3XP_017171361.1  calcium-activated potassium channel subunit alpha-1 isoform X11

    UniProtKB/TrEMBL
    A0A087WSJ2, E3VRY9
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_006518599.5XP_006518662.1  calcium-activated potassium channel subunit alpha-1 isoform X7

    UniProtKB/TrEMBL
    A0A087WSJ2, C3VLD3, E3VRY9
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_006518593.5XP_006518656.1  calcium-activated potassium channel subunit alpha-1 isoform X3

    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. XM_017315874.3XP_017171363.1  calcium-activated potassium channel subunit alpha-1 isoform X16

    UniProtKB/TrEMBL
    E3VRY8, E3VRZ1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. XM_006518606.5XP_006518669.1  calcium-activated potassium channel subunit alpha-1 isoform X15

    UniProtKB/TrEMBL
    E3VRY8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  11. XM_011244967.4XP_011243269.1  calcium-activated potassium channel subunit alpha-1 isoform X10

    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. XM_017315870.3XP_017171359.1  calcium-activated potassium channel subunit alpha-1 isoform X6

    UniProtKB/TrEMBL
    E3VRY8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  13. XM_006518595.5XP_006518658.1  calcium-activated potassium channel subunit alpha-1 isoform X5

    UniProtKB/TrEMBL
    E3VRY8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  14. XM_006518592.5XP_006518655.1  calcium-activated potassium channel subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  15. XM_006518591.5XP_006518654.1  calcium-activated potassium channel subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    C3VLD3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  16. XM_017315880.3XP_017171369.1  calcium-activated potassium channel subunit alpha-1 isoform X22

    UniProtKB/TrEMBL
    A0A286YCW3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  17. XM_017315883.3XP_017171372.1  calcium-activated potassium channel subunit alpha-1 isoform X25

    UniProtKB/TrEMBL
    A0A286YCW3
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  18. XM_017315878.3XP_017171367.1  calcium-activated potassium channel subunit alpha-1 isoform X21

    UniProtKB/TrEMBL
    E3VRY4
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  19. XM_006518605.5XP_006518668.1  calcium-activated potassium channel subunit alpha-1 isoform X14

    UniProtKB/TrEMBL
    A0A286YCW3, A0A286YDM6
    Related
    ENSMUSP00000153312.2, ENSMUST00000224468.2
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  20. XM_006518603.5XP_006518666.1  calcium-activated potassium channel subunit alpha-1 isoform X9

    UniProtKB/TrEMBL
    E3VRY4
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  21. XM_017315881.3XP_017171370.1  calcium-activated potassium channel subunit alpha-1 isoform X23

    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  22. XM_006518610.5XP_006518673.1  calcium-activated potassium channel subunit alpha-1 isoform X24

    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  23. XM_036158483.1XP_036014376.1  calcium-activated potassium channel subunit alpha-1 isoform X20

    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:538633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:446523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  24. XM_017315876.3XP_017171365.1  calcium-activated potassium channel subunit alpha-1 isoform X19

    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  25. XM_006518602.5XP_006518665.1  calcium-activated potassium channel subunit alpha-1 isoform X8

    UniProtKB/Swiss-Prot
    Q08460, Q64703, Q8VHF1, Q9R196
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  26. XM_036158484.1XP_036014377.1  calcium-activated potassium channel subunit alpha-1 isoform X26