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C1QL2 complement C1q like 2 [ Homo sapiens (human) ]

Gene ID: 165257, updated on 2-Nov-2024

Summary

Official Symbol
C1QL2provided by HGNC
Official Full Name
complement C1q like 2provided by HGNC
Primary source
HGNC:HGNC:24181
See related
Ensembl:ENSG00000144119 MIM:614330; AllianceGenome:HGNC:24181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP10; C1QTNF10
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane; postsynaptic density assembly; and regulation of synapse maturation. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse; hippocampal mossy fiber to CA3 synapse; and synaptic cleft. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See C1QL2 in Genome Data Viewer
Location:
2q14.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119156243..119158751, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119589784..119592291, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119913819..119916327, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119599819-119600399 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:119602243-119602892 and GRCh37_chr2:119602893-119603542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119607811-119608363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119610971-119611506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615003-119615764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615765-119616526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119616527-119617286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11898 Neighboring gene engrailed homeobox 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119671170-119672369 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:119711468-119712667 Neighboring gene macrophage receptor with collagenous structure Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119746563-119747064 Neighboring gene uncharacterized LOC124906072 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119749973-119751172 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119807422-119808621 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:119843263-119843429 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119868745-119869944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119870527-119871192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119891922-119892422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119892423-119892923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119914695-119915505 Neighboring gene uncharacterized LOC107985941 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119953346-119954184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119954185-119955022

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse maturation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cerebellar climbing fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic cleft IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
complement C1q-like protein 2
Names
C1q and tumor necrosis factor-related protein 10
C1q-domain containing protein
C1q/TNF-related protein 10
complement component 1, q subcomponent-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182528.4NP_872334.2  complement C1q-like protein 2 precursor

    See identical proteins and their annotated locations for NP_872334.2

    Status: VALIDATED

    Source sequence(s)
    AC016673
    Consensus CDS
    CCDS42737.1
    UniProtKB/Swiss-Prot
    Q7Z5L3
    UniProtKB/TrEMBL
    A0A3B0IND4
    Related
    ENSP00000272520.3, ENST00000272520.4
    Conserved Domains (1) summary
    pfam00386
    Location:160284
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    119156243..119158751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    119589784..119592291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)