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Kcnk1 potassium channel, subfamily K, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16525, updated on 18-Sep-2024

Summary

Official Symbol
Kcnk1provided by MGI
Official Full Name
potassium channel, subfamily K, member 1provided by MGI
Primary source
MGI:MGI:109322
See related
Ensembl:ENSMUSG00000033998 AllianceGenome:MGI:109322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TWIK-1
Summary
Enables inward rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in endosome. Is integral component of plasma membrane. Part of inward rectifier potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 45.9), cerebellum adult (RPKM 26.7) and 16 other tissues See more
Orthologs
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Genomic context

See Kcnk1 in Genome Data Viewer
Location:
8 E2; 8 73.67 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (126718692..126757424)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (125993655..126030685)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31069 Neighboring gene predicted gene, 42056 Neighboring gene STARR-seq mESC enhancer starr_23054 Neighboring gene STARR-seq mESC enhancer starr_23055 Neighboring gene predicted gene, 53470 Neighboring gene predicted gene, 46072 Neighboring gene solute carrier family 35, member F3 Neighboring gene predicted gene, 31165

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium ion leak channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion leak channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables sodium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of inward rectifier potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 1
Names
inward rectifying potassium channel protein TWIK-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008430.2NP_032456.2  potassium channel subfamily K member 1

    See identical proteins and their annotated locations for NP_032456.2

    Status: VALIDATED

    Source sequence(s)
    AC102420, AF033017, AK137224, BG088333, BY240683
    Consensus CDS
    CCDS22783.1
    UniProtKB/Swiss-Prot
    O08581, Q99L99
    Related
    ENSMUSP00000046103.9, ENSMUST00000046765.10
    Conserved Domains (1) summary
    pfam07885
    Location:100157
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    126718692..126757424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530716.4XP_006530779.1  potassium channel subfamily K member 1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5RMH2
    Related
    ENSMUSP00000148778.2, ENSMUST00000212831.2
    Conserved Domains (1) summary
    pfam07885
    Location:88157
    Ion_trans_2; Ion channel