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Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 [ Mus musculus (house mouse) ]

Gene ID: 16523, updated on 25-Jan-2022

Summary

Official Symbol
Kcnj8provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 8provided by MGI
Primary source
MGI:MGI:1100508
See related
Ensembl:ENSMUSG00000030247 AllianceGenome:MGI:1100508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sltr; gnite; slmbr; Kir6.1; uKATP-1; AI448900
Summary
Predicted to enable several functions, including ATP binding activity; sulfonylurea receptor binding activity; and voltage-gated potassium channel activity. Acts upstream of or within several processes, including defense response to virus; response to exogenous dsRNA; and response to lipopolysaccharide. Located in myofibril. Is expressed in genitourinary system and heart. Used to study coronary artery disease and hypertrichotic osteochondrodysplasia Cantu type. Orthologous to human KCNJ8 (potassium inwardly rectifying channel subfamily J member 8). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 13.7), heart adult (RPKM 13.0) and 25 other tissues See more
Orthologs
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Genomic context

See Kcnj8 in Genome Data Viewer
Location:
6 G2; 6 74.31 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142510563..142517340, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142564837..142571614, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142513459..142519876, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46979 Neighboring gene predicted gene, 38920 Neighboring gene RIKEN cDNA 5330439B14 gene Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
part_of inward rectifying potassium channel ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 8
Names
inward rectifier K(+) channel Kir6.1
inwardly rectifier K(+) channel Kir6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330363.1NP_001317292.1  ATP-sensitive inward rectifier potassium channel 8 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA672233, AC121611, BY252361, CJ238449, CK389528
    Consensus CDS
    CCDS20685.1
    UniProtKB/Swiss-Prot
    P97794
    UniProtKB/TrEMBL
    Q3U118
    Conserved Domains (2) summary
    pfam01007
    Location:37184
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:191363
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. NM_001330366.1NP_001317295.1  ATP-sensitive inward rectifier potassium channel 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK031777, CJ238449, CK389528
    Consensus CDS
    CCDS90135.1
    UniProtKB/TrEMBL
    A0A0J9YMM3
    Related
    ENSMUSP00000032374.9, ENSMUST00000032374.9
  3. NM_008428.5NP_032454.1  ATP-sensitive inward rectifier potassium channel 8 isoform 1

    See identical proteins and their annotated locations for NP_032454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA672233, AC121611, CJ238449, CK389528
    Consensus CDS
    CCDS20685.1
    UniProtKB/Swiss-Prot
    P97794
    UniProtKB/TrEMBL
    Q3U118
    Related
    ENSMUSP00000145440.2, ENSMUST00000203945.3
    Conserved Domains (2) summary
    pfam01007
    Location:37184
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:191363
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142510563..142517340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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