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Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [ Mus musculus (house mouse) ]

Gene ID: 16522, updated on 18-Sep-2024

Summary

Official Symbol
Kcnj6provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 6provided by MGI
Primary source
MGI:MGI:104781
See related
Ensembl:ENSMUSG00000043301 AllianceGenome:MGI:104781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver
Summary
Enables G-protein activated inward rectifier potassium channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.9), testis adult (RPKM 1.8) and 5 other tissues See more
Orthologs
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Genomic context

See Kcnj6 in Genome Data Viewer
Location:
16 C4; 16 55.44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94545839..94798719, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94744980..94997696, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41505 Neighboring gene predicted gene, 41507 Neighboring gene STARR-seq mESC enhancer starr_41586 Neighboring gene STARR-seq mESC enhancer starr_41589 Neighboring gene STARR-seq mESC enhancer starr_41593 Neighboring gene STARR-seq mESC enhancer starr_41595 Neighboring gene predicted gene, 31407 Neighboring gene STARR-seq mESC enhancer starr_41597 Neighboring gene STARR-seq mESC enhancer starr_41598 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G protein-activated inward rectifier potassium channel 2
Names
G-protein-coupled inward rectifier K+ channel 2-1
G-protein-coupled inward rectifier K+ channel 2-A
G-protein-coupled inward rectifier K+ channel 2-B
G-protein-coupled inward rectifier K+ channel 2-C
GIRK-2
inward rectifier K(+) channel Kir3.2
potassium channel, inwardly rectifying subfamily J member 6
potassium inwardly-rectifying channel J6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025584.2NP_001020755.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2-1

    See identical proteins and their annotated locations for NP_001020755.1

    Status: VALIDATED

    Source sequence(s)
    AK081109, BB591362
    Consensus CDS
    CCDS37408.1
    UniProtKB/TrEMBL
    Q3UTV4, Q8C4T8
    Related
    ENSMUSP00000093558.5, ENSMUST00000095873.12
    Conserved Domains (2) summary
    pfam01007
    Location:59198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205374
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. NM_001025585.2NP_001020756.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2B

    See identical proteins and their annotated locations for NP_001020756.1

    Status: VALIDATED

    Source sequence(s)
    BB277039, BB591362, D86040
    UniProtKB/TrEMBL
    Q8C8Y6
    Related
    ENSMUST00000232403.2
    Conserved Domains (1) summary
    cl21560
    Location:59318
    Ion_trans_2; Ion channel
  3. NM_001025590.2NP_001020761.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2C

    See identical proteins and their annotated locations for NP_001020761.1

    Status: VALIDATED

    Source sequence(s)
    AC165248
    Consensus CDS
    CCDS49921.1
    UniProtKB/TrEMBL
    A0A0R4J239, Q8C8Y6
    Related
    ENSMUSP00000130321.2, ENSMUST00000165538.3
    Conserved Domains (1) summary
    cl21560
    Location:41302
    Ion_trans_2; Ion channel
  4. NM_010606.2NP_034736.2  G protein-activated inward rectifier potassium channel 2 isoform Girk2A-1

    See identical proteins and their annotated locations for NP_034736.2

    Status: VALIDATED

    Source sequence(s)
    AB029502, AC165271, AK044218, BB591362
    Consensus CDS
    CCDS37409.1
    UniProtKB/TrEMBL
    Q0VB45, Q3UTV4
    Related
    ENSMUSP00000097108.3, ENSMUST00000099508.4
    Conserved Domains (2) summary
    pfam01007
    Location:59198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205374
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    94545839..94798719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246104.2XP_011244406.1  G protein-activated inward rectifier potassium channel 2 isoform X1

    See identical proteins and their annotated locations for XP_011244406.1

    UniProtKB/TrEMBL
    A0A338P6L0, Q3UTV4
    Related
    ENSMUSP00000156014.2, ENSMUST00000232562.2
    Conserved Domains (2) summary
    pfam01007
    Location:41180
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:187356
    IRK_C; Inward rectifier potassium channel C-terminal domain

RNA

  1. XR_004939169.1 RNA Sequence