U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [ Mus musculus (house mouse) ]

Gene ID: 16521, updated on 10-Oct-2024

Summary

Official Symbol
Kcnj5provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 5provided by MGI
Primary source
MGI:MGI:104755
See related
Ensembl:ENSMUSG00000032034 AllianceGenome:MGI:104755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIR; GIRK4; KATP-1; Kir3.4
Summary
Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in T-tubule and external side of plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; heart; intestine; liver lobe; and placenta. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 14.0), liver E14 (RPKM 0.9) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnj5 in Genome Data Viewer
Location:
9 A4; 9 17.65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32226002..32255640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32314706..32344380, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 32 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23720 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23722 Neighboring gene STARR-seq mESC enhancer starr_23724 Neighboring gene STARR-seq mESC enhancer starr_23725 Neighboring gene STARR-positive B cell enhancer ABC_E9755 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32094558-32094858 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32157923-32158223 Neighboring gene STARR-positive B cell enhancer ABC_E38 Neighboring gene STARR-seq mESC enhancer starr_23730 Neighboring gene STARR-seq mESC enhancer starr_23731 Neighboring gene predicted gene, 39317 Neighboring gene predicted gene, 31755 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of I(KACh) inward rectifier potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G protein-activated inward rectifier potassium channel 4
Names
cardiac inward rectifier
heart KATP channel
inward rectifier K(+) channel Kir3.4
potassium channel, inwardly rectifying subfamily J member 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411833.1NP_001398762.1  G protein-activated inward rectifier potassium channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132114
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9
    Related
    ENSMUSP00000149000.2, ENSMUST00000214223.2
  2. NM_001411834.1NP_001398763.1  G protein-activated inward rectifier potassium channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132114
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9
  3. NM_001411835.1NP_001398764.1  G protein-activated inward rectifier potassium channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132114
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9
  4. NM_001411836.1NP_001398765.1  G protein-activated inward rectifier potassium channel 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132114
  5. NM_010605.6NP_034735.3  G protein-activated inward rectifier potassium channel 4 isoform 1

    See identical proteins and their annotated locations for NP_034735.3

    Status: VALIDATED

    Source sequence(s)
    AC132114
    Consensus CDS
    CCDS22952.1
    UniProtKB/Swiss-Prot
    P48545, P97508, Q3TPX9
    UniProtKB/TrEMBL
    Q9QYM1
    Related
    ENSMUSP00000034533.6, ENSMUST00000034533.7
    Conserved Domains (2) summary
    pfam01007
    Location:54193
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:200371
    IRK_C; Inward rectifier potassium channel C-terminal domain

RNA

  1. NR_157190.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132114

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    32226002..32255640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313154.3XP_017168643.1  G protein-activated inward rectifier potassium channel 4 isoform X1

    UniProtKB/TrEMBL
    Q9QYM1
    Conserved Domains (2) summary
    pfam01007
    Location:103242
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:249420
    IRK_C; Inward rectifier potassium channel C-terminal domain