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Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 [ Mus musculus (house mouse) ]

Gene ID: 16520, updated on 18-Sep-2024

Summary

Official Symbol
Kcnj4provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 4provided by MGI
Primary source
MGI:MGI:104743
See related
Ensembl:ENSMUSG00000044216 AllianceGenome:MGI:104743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRK3; Kcnf2; MB-IRK3
Summary
Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; epididymis; telencephalon; and thymus. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 17.6) and cortex adult (RPKM 11.2) See more
Orthologs
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Genomic context

See Kcnj4 in Genome Data Viewer
Location:
15 E1; 15 37.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79364427..79396712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79480226..79512511, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359 Neighboring gene STARR-seq mESC enhancer starr_39188 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39189 Neighboring gene DEAD box helicase 17 Neighboring gene DNA meiotic recombinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inward rectifier potassium channel 4
Names
IRK-3
Kir 2.3
inward rectifier K(+) channel Kir2.3
potassium channel, inwardly rectifying subfamily J member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008427.5NP_032453.3  inward rectifier potassium channel 4

    See identical proteins and their annotated locations for NP_032453.3

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27641.1
    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Related
    ENSMUSP00000094075.4, ENSMUST00000057801.8
    Conserved Domains (2) summary
    pfam01007
    Location:22177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184356
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79364427..79396712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520486.4XP_006520549.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006520549.1

    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Conserved Domains (2) summary
    pfam01007
    Location:22177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184356
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. XM_006520488.4XP_006520551.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006520551.1

    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Conserved Domains (2) summary
    pfam01007
    Location:22177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184356
    IRK_C; Inward rectifier potassium channel C-terminal domain
  3. XM_006520487.5XP_006520550.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006520550.1

    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Conserved Domains (2) summary
    pfam01007
    Location:22177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184356
    IRK_C; Inward rectifier potassium channel C-terminal domain