Format

Send to:

Choose Destination

DDT D-dopachrome tautomerase [ Homo sapiens (human) ]

Gene ID: 1652, updated on 5-Jan-2022

Summary

Official Symbol
DDTprovided by HGNC
Official Full Name
D-dopachrome tautomeraseprovided by HGNC
Primary source
HGNC:HGNC:2732
See related
Ensembl:ENSG00000099977 Ensembl:ENSG00000285762 MIM:602750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D-DT; DDCT; MIF2; MIF-2
Summary
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Expression
Broad expression in liver (RPKM 108.4), kidney (RPKM 65.2) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DDT in Genome Data Viewer
Location:
22q11.23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (23971370..23980504, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24313559..24322019, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase theta-4-like Neighboring gene glutathione S-transferase theta 2B Neighboring gene D-dopachrome tautomerase like Neighboring gene glutathione S-transferase theta 2 (gene/pseudogene) Neighboring gene glutathione S-transferase theta 4 Neighboring gene uncharacterized LOC105372959

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ78842

General protein information

Preferred Names
D-dopachrome decarboxylase
Names
phenylpyruvate tautomerase II
NP_001077861.1
NP_001346.1
NP_001368781.1
NP_001384414.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001084392.3NP_001077861.1  D-dopachrome decarboxylase isoform a

    See identical proteins and their annotated locations for NP_001077861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC253536
    Consensus CDS
    CCDS13820.1
    UniProtKB/Swiss-Prot
    P30046
    UniProtKB/TrEMBL
    Q53Y51
    Related
    ENSP00000381386.4, ENST00000398344.9
    Conserved Domains (1) summary
    pfam01187
    Location:2116
    MIF; Macrophage migration inhibitory factor (MIF)
  2. NM_001355.4NP_001346.1  D-dopachrome decarboxylase isoform a

    See identical proteins and their annotated locations for NP_001346.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AP000351, CA414359, U49785
    Consensus CDS
    CCDS13820.1
    UniProtKB/Swiss-Prot
    P30046
    UniProtKB/TrEMBL
    Q53Y51
    Related
    ENSP00000215773.4, ENST00000350608.7
    Conserved Domains (1) summary
    pfam01187
    Location:2116
    MIF; Macrophage migration inhibitory factor (MIF)
  3. NM_001381852.2NP_001368781.1  D-dopachrome decarboxylase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (b).
    Source sequence(s)
    AC253536
    Related
    ENSP00000384866.3, ENST00000403754.7
    Conserved Domains (1) summary
    cl00235
    Location:2100
    4Oxalocrotonate_Tautomerase; 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one ...
  4. NM_001397485.1NP_001384414.1  D-dopachrome decarboxylase isoform a

    Status: REVIEWED

    Source sequence(s)
    AC253536

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    23971370..23980504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    207734..216870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center