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DDT D-dopachrome tautomerase [ Homo sapiens (human) ]

Gene ID: 1652, updated on 13-Jan-2019

Summary

Official Symbol
DDTprovided by HGNC
Official Full Name
D-dopachrome tautomeraseprovided by HGNC
Primary source
HGNC:HGNC:2732
See related
Ensembl:ENSG00000099977 MIM:602750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D-DT; DDCT; MIF2; MIF-2
Summary
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Expression
Broad expression in liver (RPKM 108.4), kidney (RPKM 65.2) and 23 other tissues See more
Orthologs

Genomic context

See DDT in Genome Data Viewer
Location:
22q11.23
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (23971365..23979828, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24313554..24322019, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase theta-4-like Neighboring gene glutathione S-transferase theta 2B (gene/pseudogene) Neighboring gene D-dopachrome tautomerase like Neighboring gene glutathione S-transferase theta 2 (gene/pseudogene) Neighboring gene glutathione S-transferase theta 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ78842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-dopachrome decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
cytokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
dopachrome isomerase activity TAS
Traceable Author Statement
more info
PubMed 
phenylpyruvate tautomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
D-dopachrome decarboxylase
Names
phenylpyruvate tautomerase II
NP_001077861.1
NP_001346.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001084392.1NP_001077861.1  D-dopachrome decarboxylase

    See identical proteins and their annotated locations for NP_001077861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP000351, BC015508, CA414359
    Consensus CDS
    CCDS13820.1
    UniProtKB/Swiss-Prot
    P30046
    UniProtKB/TrEMBL
    Q53Y51
    Related
    ENSP00000381386.4, ENST00000398344.8
    Conserved Domains (1) summary
    pfam01187
    Location:2116
    MIF; Macrophage migration inhibitory factor (MIF)
  2. NM_001355.3NP_001346.1  D-dopachrome decarboxylase

    See identical proteins and their annotated locations for NP_001346.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AP000351, CA414359, U49785
    Consensus CDS
    CCDS13820.1
    UniProtKB/Swiss-Prot
    P30046
    UniProtKB/TrEMBL
    Q53Y51
    Related
    ENSP00000215773.4, ENST00000350608.7
    Conserved Domains (1) summary
    pfam01187
    Location:2116
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    23971365..23979828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    207729..216194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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