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Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 [ Mus musculus (house mouse) ]

Gene ID: 16519, updated on 19-Sep-2024

Summary

Official Symbol
Kcnj3provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 3provided by MGI
Primary source
MGI:MGI:104742
See related
Ensembl:ENSMUSG00000026824 AllianceGenome:MGI:104742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIRK1; Kcnf3; Kcnj1; GIRK-1; Kir3.1
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within ion transport. Is active in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; male reproductive gland or organ; and thymus. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 9.5), heart adult (RPKM 8.9) and 6 other tissues See more
Orthologs
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Genomic context

See Kcnj3 in Genome Data Viewer
Location:
2 C1.1; 2 31.66 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (55301814..55488157)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (55411798..55598145)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 13 Neighboring gene predicted gene, 25489 Neighboring gene STARR-seq mESC enhancer starr_04517 Neighboring gene STARR-seq mESC enhancer starr_04518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:55104656-55104956 Neighboring gene cathepsin B pseudogene Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene oral-facial-digital syndrome 1 gene homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124233, MGC124234

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of I(KACh) inward rectifier potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G protein-activated inward rectifier potassium channel 1
Names
G protein-gated K+ channel subunit 1 GIRK1
inward rectifier K(+) channel Kir3.1
potassium channel, inwardly rectifying subfamily J member 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304810.1NP_001291739.1  G protein-activated inward rectifier potassium channel 1 isoform 2

    See identical proteins and their annotated locations for NP_001291739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL929253, AW488293, BC068167
    Consensus CDS
    CCDS84524.1
    UniProtKB/TrEMBL
    B1AYE4, Q8VHS4
    Related
    ENSMUSP00000108251.2, ENSMUST00000112632.2
    Conserved Domains (1) summary
    cl21560
    Location:47234
    Ion_trans_2; Ion channel
  2. NM_001355118.1NP_001342047.1  G protein-activated inward rectifier potassium channel 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL845483, AL929253
    Consensus CDS
    CCDS16042.1
    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  3. NM_008426.2NP_032452.1  G protein-activated inward rectifier potassium channel 1 isoform 1

    See identical proteins and their annotated locations for NP_032452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AL929253, AW488293, BC068167
    Consensus CDS
    CCDS16042.1
    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Related
    ENSMUSP00000063329.4, ENSMUST00000067101.10
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    55301814..55488157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247723.2XP_030103583.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. XM_036158746.1XP_036014639.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  3. XM_030247737.2XP_030103597.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  4. XM_030247725.2XP_030103585.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  5. XM_030247736.2XP_030103596.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  6. XM_030247738.2XP_030103598.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  7. XM_030247730.2XP_030103590.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  8. XM_030247739.2XP_030103599.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  9. XM_030247729.2XP_030103589.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  10. XM_030247740.2XP_030103600.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  11. XM_036158749.1XP_036014642.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  12. XM_030247752.2XP_030103612.1  G protein-activated inward rectifier potassium channel 1 isoform X3

    Conserved Domains (1) summary
    pfam17655
    Location:2132
    IRK_C; Inward rectifier potassium channel C-terminal domain
  13. XM_030247722.2XP_030103582.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  14. XM_030247751.2XP_030103611.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  15. XM_030247749.2XP_030103609.1  G protein-activated inward rectifier potassium channel 1 isoform X1

    UniProtKB/Swiss-Prot
    P35562, P63250
    UniProtKB/TrEMBL
    Q3ZAT1
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194364
    IRK_C; Inward rectifier potassium channel C-terminal domain
  16. XM_006497731.5XP_006497794.1  G protein-activated inward rectifier potassium channel 1 isoform X2

    UniProtKB/TrEMBL
    Q8VHS4
    Conserved Domains (2) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:194240
    IRK_C; Inward rectifier potassium channel C-terminal domain