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Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16518, updated on 10-Jun-2024

Summary

Official Symbol
Kcnj2provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 2provided by MGI
Primary source
MGI:MGI:104744
See related
Ensembl:ENSMUSG00000041695 AllianceGenome:MGI:104744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRK1; Kcnf1; Kir2.1
Summary
Enables identical protein binding activity. Acts upstream of or within cardiac muscle cell action potential and magnesium ion transport. Predicted to be located in several cellular components, including T-tubule; endoplasmic reticulum; and intercalated disc. Predicted to be intrinsic component of membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 5.9), cortex adult (RPKM 2.9) and 18 other tissues See more
Orthologs
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Genomic context

See Kcnj2 in Genome Data Viewer
Location:
11 E2; 11 75.23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (110956990..110967651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (111066164..111076825)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:110420525-110420826 Neighboring gene predicted gene, 46300 Neighboring gene STARR-seq mESC enhancer starr_31046 Neighboring gene STARR-seq mESC enhancer starr_31047 Neighboring gene STARR-seq mESC enhancer starr_31048 Neighboring gene STARR-seq mESC enhancer starr_31049 Neighboring gene STARR-positive B cell enhancer ABC_E5296 Neighboring gene STARR-positive B cell enhancer ABC_E4011 Neighboring gene STARR-seq mESC enhancer starr_31050 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 16 Neighboring gene STARR-seq mESC enhancer starr_31052 Neighboring gene STARR-seq mESC enhancer starr_31053 Neighboring gene predicted gene, 53651 Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene Neighboring gene STARR-seq mESC enhancer starr_31055 Neighboring gene predicted gene, 30158

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell action potential involved in contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within magnesium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane repolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane repolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of skeletal muscle contraction via regulation of action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in relaxation of skeletal muscle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inward rectifier potassium channel 2
Names
IRK-1
inward rectifier K(+) channel Kir2.1
potassium channel, inwardly rectifying subfamily J member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008425.4NP_032451.1  inward rectifier potassium channel 2

    See identical proteins and their annotated locations for NP_032451.1

    Status: VALIDATED

    Source sequence(s)
    AK044915, AL662912, BB642909, BP762467
    Consensus CDS
    CCDS25594.1
    UniProtKB/Swiss-Prot
    P35561
    UniProtKB/TrEMBL
    Q543W5
    Related
    ENSMUSP00000037192.3, ENSMUST00000042970.3
    Conserved Domains (2) summary
    pfam01007
    Location:48373
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:247
    IRK_N; Inward rectifier potassium channel N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    110956990..110967651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)