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Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 [ Mus musculus (house mouse) ]

Gene ID: 16517, updated on 19-Sep-2024

Summary

Official Symbol
Kcnj16provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 16provided by MGI
Primary source
MGI:MGI:1314842
See related
Ensembl:ENSMUSG00000051497 AllianceGenome:MGI:1314842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kir5.1; 6430410F18Rik
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including potassium ion import across plasma membrane; regulation of pH; and response to carbon dioxide. Predicted to act upstream of or within ion transport. Located in plasma membrane. Is expressed in floor plate; heart; and metanephros. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 63.6), frontal lobe adult (RPKM 5.2) and 3 other tissues See more
Orthologs
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Genomic context

See Kcnj16 in Genome Data Viewer
Location:
11 E2; 11 75.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (110858859..110918794)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110968033..111027968)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:110420525-110420826 Neighboring gene predicted gene 11682 Neighboring gene predicted gene, 46300 Neighboring gene STARR-seq mESC enhancer starr_31046 Neighboring gene STARR-seq mESC enhancer starr_31047 Neighboring gene STARR-seq mESC enhancer starr_31048 Neighboring gene STARR-seq mESC enhancer starr_31049 Neighboring gene STARR-positive B cell enhancer ABC_E5296 Neighboring gene STARR-positive B cell enhancer ABC_E4011 Neighboring gene STARR-seq mESC enhancer starr_31050 Neighboring gene STARR-seq mESC enhancer starr_31052 Neighboring gene STARR-seq mESC enhancer starr_31053 Neighboring gene predicted gene, 53651 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 2 Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
 
involved_in response to carbon dioxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inward rectifier potassium channel 16
Names
inward rectifier K(+) channel Kir5.1
potassium channel, inwardly rectifying subfamily J member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252207.1NP_001239136.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK032192, AK078905, AL592422, AW122947, BB848241
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000136382.2, ENSMUST00000180023.8
    Conserved Domains (2) summary
    pfam01007
    Location:37173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. NM_001252208.1NP_001239137.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AL592422, AW122947, BB850391
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000137414.2, ENSMUST00000178798.2
    Conserved Domains (2) summary
    pfam01007
    Location:37173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  3. NM_001252209.2NP_001239138.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK045447, AL592422, AW122947
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000102246.2, ENSMUST00000106635.2
    Conserved Domains (2) summary
    pfam01007
    Location:37173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  4. NM_001252210.2NP_001239139.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AL592422
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Conserved Domains (2) summary
    pfam01007
    Location:37173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182349
    IRK_C; Inward rectifier potassium channel C-terminal domain
  5. NM_010604.3NP_034734.3  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_034734.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK078905, AL592422
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000102247.2, ENSMUST00000106636.8
    Conserved Domains (2) summary
    pfam01007
    Location:37173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182349
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    110858859..110918794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156350.1XP_036012243.1  inward rectifier potassium channel 16 isoform X1

    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Conserved Domains (2) summary
    pfam01007
    Location:37173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182349
    IRK_C; Inward rectifier potassium channel C-terminal domain