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Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 [ Mus musculus (house mouse) ]

Gene ID: 16515, updated on 23-May-2018
Official Symbol
Kcnj12provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 12provided by MGI
Primary source
MGI:MGI:108495
See related
Ensembl:ENSMUSG00000042529 Vega:OTTMUSG00000005827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRK2; IRK-2; Kir2.2; MB-IRK2
Expression
Biased expression in cerebellum adult (RPKM 14.1), heart adult (RPKM 8.7) and 11 other tissues See more
Orthologs
See Kcnj12 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (61022564..61073269)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60879306..60884633)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 3 Neighboring gene predicted gene, 35681 Neighboring gene predicted gene, 46283 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene ubiquitin specific peptidase 22

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC144838, MGC144839

Gene Ontology Provided by MGI

Function Evidence Code Pubs
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ion transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
T-tubule ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ATP-sensitive inward rectifier potassium channel 12
Names
inward rectifier K(+) channel Kir2.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267593.1NP_001254522.1  ATP-sensitive inward rectifier potassium channel 12 isoform 2

    See identical proteins and their annotated locations for NP_001254522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK032271, AL646093
    Consensus CDS
    CCDS24805.1
    UniProtKB/Swiss-Prot
    P52187
    Related
    ENSMUSP00000086588.4, OTTMUSP00000006015, ENSMUST00000089184.10, OTTMUST00000012929
    Conserved Domains (2) summary
    pfam01007
    Location:47374
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:346
    IRK_N; Inward rectifier potassium channel N-terminal
  2. NM_010603.6NP_034733.4  ATP-sensitive inward rectifier potassium channel 12 isoform 1

    See identical proteins and their annotated locations for NP_034733.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK017299, AL646093
    Consensus CDS
    CCDS59563.1
    UniProtKB/TrEMBL
    B1ATI1, Q9D3L6
    Related
    ENSMUSP00000041696.2, OTTMUSP00000006016, ENSMUST00000041944.8, OTTMUST00000012930
    Conserved Domains (2) summary
    pfam01007
    Location:149476
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:105148
    IRK_N; Inward rectifier potassium channel N-terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    61022564..61073269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532318.3XP_006532381.1  ATP-sensitive inward rectifier potassium channel 12 isoform X1

    See identical proteins and their annotated locations for XP_006532381.1

    UniProtKB/Swiss-Prot
    P52187
    Related
    ENSMUSP00000104357.2, ENSMUST00000108717.2
    Conserved Domains (2) summary
    pfam01007
    Location:47374
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:346
    IRK_N; Inward rectifier potassium channel N-terminal
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