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Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 [ Mus musculus (house mouse) ]

Gene ID: 16515, updated on 16-Oct-2021

Summary

Official Symbol
Kcnj12provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 12provided by MGI
Primary source
MGI:MGI:108495
See related
Ensembl:ENSMUSG00000042529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRK2; IRK-2; Kir2.2; MB-IRK2
Expression
Biased expression in cerebellum adult (RPKM 14.1), heart adult (RPKM 8.7) and 11 other tissues See more
Orthologs
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Genomic context

See Kcnj12 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60912970..60964095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61022564..61073269)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60879306..60884633)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 3 Neighboring gene predicted gene, 35681 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene ubiquitin specific peptidase 22

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC144838, MGC144839

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 12
Names
inward rectifier K(+) channel Kir2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267593.1NP_001254522.1  ATP-sensitive inward rectifier potassium channel 12 isoform 2

    See identical proteins and their annotated locations for NP_001254522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK032271, AL646093
    Consensus CDS
    CCDS24805.1
    UniProtKB/Swiss-Prot
    P52187
    Related
    ENSMUSP00000086588.5, ENSMUST00000089184.11
    Conserved Domains (3) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:246
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:194366
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. NM_010603.6NP_034733.4  ATP-sensitive inward rectifier potassium channel 12 isoform 1

    See identical proteins and their annotated locations for NP_034733.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK017299, AL646093
    Consensus CDS
    CCDS59563.1
    UniProtKB/TrEMBL
    B1ATI1, Q9D3L6
    Related
    ENSMUSP00000041696.3, ENSMUST00000041944.9
    Conserved Domains (4) summary
    PRK07764
    Location:9111
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01007
    Location:149289
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:104148
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:296468
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60912970..60964095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156349.1XP_036012242.1  ATP-sensitive inward rectifier potassium channel 12 isoform X2

    Related
    ENSMUSP00000104357.3, ENSMUST00000108717.3
    Conserved Domains (3) summary
    pfam01007
    Location:47187
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:246
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:194366
    IRK_C; Inward rectifier potassium channel C-terminal domain
  2. XM_030245606.2XP_030101466.1  ATP-sensitive inward rectifier potassium channel 12 isoform X1

    Conserved Domains (4) summary
    PRK07764
    Location:9111
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01007
    Location:149289
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:104148
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:296468
    IRK_C; Inward rectifier potassium channel C-terminal domain
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