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Kcnj12 potassium inwardly-rectifying channel, subfamily J, member 12 [ Mus musculus (house mouse) ]

Gene ID: 16515, updated on 18-Sep-2024

Summary

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Official Symbol
Kcnj12provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 12provided by MGI
Primary source
MGI:MGI:108495
See related
Ensembl:ENSMUSG00000042529 AllianceGenome:MGI:108495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRK2; IRK-2; Kir2.2; MB-IRK2
Summary
Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in T-tubule; dendrite; and neuronal cell body. Predicted to be intrinsic component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb segment. Orthologous to several human genes including KCNJ12 (potassium inwardly rectifying channel subfamily J member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 14.1), heart adult (RPKM 8.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnj12 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60912970..60964095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61022564..61073269)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2993 Neighboring gene mitogen-activated protein kinase kinase 3 Neighboring gene predicted gene, 35681 Neighboring gene STARR-positive B cell enhancer ABC_E8878 Neighboring gene STARR-positive B cell enhancer ABC_E5234 Neighboring gene STARR-positive B cell enhancer ABC_E8412 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene STARR-positive B cell enhancer ABC_E3956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60973670-60973823 Neighboring gene STARR-positive B cell enhancer ABC_E374 Neighboring gene ubiquitin specific peptidase 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse. Oyamada Y, et al. Respir Physiol Neurobiol, 2005 Feb 15. PMID 15705530
  2. Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels. Ishihara K, et al. J Physiol, 2007 Sep 15. PMID 17640933, Free PMC Article
  3. The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes. Zaritsky JJ, et al. J Physiol, 2001 Jun 15. PMID 11410627, Free PMC Article
  4. Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Zaritsky JJ, et al. Circ Res, 2000 Jul 21. PMID 10904001
  5. Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. Takahashi N, et al. J Biol Chem, 1994 Sep 16. PMID 8083233

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
    Title: A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.
  2. Kir2 channels exist in two states having different susceptibilities to internal cationic blockers
    Title: Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.
  3. Kir2.2 in the brainstem plays a transient role in hypercapnic ventilatory response , possibly through central ventilatory chemosensitivity, during postnatal development.
    Title: Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.
  4. Computer simulations grounded in biophysical measurements of prelimbic and infralimbic cortex slices suggest a dynamic interaction among Kir2, Kleak, and HCN channel currents in shaping membrane potential and temporal integration of synaptic potentials.
    Title: Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144838, MGC144839

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-sensitive inward rectifier potassium channel 12
Names
inward rectifier K(+) channel Kir2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267593.1 → NP_001254522.1  ATP-sensitive inward rectifier potassium channel 12 isoform 2

    See identical proteins and their annotated locations for NP_001254522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK032271, AL646093
    Consensus CDS
    CCDS24805.1
    UniProtKB/Swiss-Prot
    P52187, Q8CCR0, Q9QYF2
    UniProtKB/TrEMBL
    Q9D3L6
    Related
    ENSMUSP00000086588.5, ENSMUST00000089184.11
    Conserved Domains (3) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:2 → 46
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:194 → 366
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. NM_010603.6 → NP_034733.4  ATP-sensitive inward rectifier potassium channel 12 isoform 1

    See identical proteins and their annotated locations for NP_034733.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK017299, AL646093
    Consensus CDS
    CCDS59563.1
    UniProtKB/TrEMBL
    B1ATI1, Q9D3L6
    Related
    ENSMUSP00000041696.3, ENSMUST00000041944.9
    Conserved Domains (4) summary
    PRK07764
    Location:9 → 111
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01007
    Location:149 → 289
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:104 → 148
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:296 → 468
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60912970..60964095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156349.1 → XP_036012242.1  ATP-sensitive inward rectifier potassium channel 12 isoform X2

    UniProtKB/Swiss-Prot
    P52187, Q8CCR0, Q9QYF2
    UniProtKB/TrEMBL
    Q9D3L6
    Related
    ENSMUSP00000104357.3, ENSMUST00000108717.3
    Conserved Domains (3) summary
    pfam01007
    Location:47 → 187
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:2 → 46
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:194 → 366
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_030245606.2 → XP_030101466.1  ATP-sensitive inward rectifier potassium channel 12 isoform X1

    UniProtKB/TrEMBL
    B1ATI1, Q9D3L6
    Conserved Domains (4) summary
    PRK07764
    Location:9 → 111
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    pfam01007
    Location:149 → 289
    IRK; Inward rectifier potassium channel
    pfam08466
    Location:104 → 148
    IRK_N; Inward rectifier potassium channel N-terminal
    pfam17655
    Location:296 → 468
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52187.2 GenPept UniProtKB/Swiss-Prot:P52187

Gene LinkOut

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