U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 [ Mus musculus (house mouse) ]

Gene ID: 16514, updated on 10-Oct-2024

Summary

Official Symbol
Kcnj11provided by MGI
Official Full Name
potassium inwardly rectifying channel, subfamily J, member 11provided by MGI
Primary source
MGI:MGI:107501
See related
Ensembl:ENSMUSG00000096146 AllianceGenome:MGI:107501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mBIR; Kir6.2
Summary
Enables ATP binding activity; ATP-activated inward rectifier potassium channel activity; and ankyrin binding activity. Involved in potassium ion import across plasma membrane. Located in T-tubule. Part of inward rectifying potassium channel. Is expressed in several structures, including brain; cardiovascular system; gut; skeletal muscle tissue; and testis. Used to study permanent neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 35.0), cortex adult (RPKM 10.2) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnj11 in Genome Data Viewer
Location:
7 B3; 7 29.66 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45746545..45750215, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46097123..46100952, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nodal modulator 1 Neighboring gene predicted gene, 39010 Neighboring gene erythrocyte protein band 4.1-like 5 pseudogene Neighboring gene predicted gene, 51481 Neighboring gene ATP-binding cassette, sub-family C member 8 Neighboring gene USH1 protein network component harmonin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-activated inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-activated inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-activated inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled monoatomic cation transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables inward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables potassium ion binding IC
Inferred by Curator
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within CAMKK-AMPK signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within action potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nicotine IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to nutrient levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in inorganic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system process IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ATP ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to resveratrol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma IEA
Inferred from Electronic Annotation
more info
 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in cell body fiber IEA
Inferred from Electronic Annotation
more info
 
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
part_of inward rectifying potassium channel IDA
Inferred from Direct Assay
more info
PubMed 
part_of inward rectifying potassium channel ISO
Inferred from Sequence Orthology
more info
 
part_of inward rectifying potassium channel ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 11
Names
inward rectifier K(+) channel Kir6.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204411.2NP_001191340.1  ATP-sensitive inward rectifier potassium channel 11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC115036
    UniProtKB/TrEMBL
    Q8CCI6
    Related
    ENSMUSP00000136002.3, ENSMUST00000180081.3
    Conserved Domains (1) summary
    cl21560
    Location:1269
    Ion_trans_2; Ion channel
  2. NM_001412604.1NP_001399533.1  ATP-sensitive inward rectifier potassium channel 11 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC115036
  3. NM_010602.4NP_034732.1  ATP-sensitive inward rectifier potassium channel 11 isoform 1

    See identical proteins and their annotated locations for NP_034732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC115036
    Consensus CDS
    CCDS21274.1
    UniProtKB/Swiss-Prot
    Q61743, Q9QX21
    UniProtKB/TrEMBL
    Q8CCI6
    Related
    ENSMUSP00000147439.2, ENSMUST00000211674.2
    Conserved Domains (2) summary
    pfam01007
    Location:36174
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:181354
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45746545..45750215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)