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Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 [ Mus musculus (house mouse) ]

Gene ID: 16513, updated on 24-Sep-2024

Summary

Official Symbol
Kcnj10provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 10provided by MGI
Primary source
MGI:MGI:1194504
See related
Ensembl:ENSMUSG00000044708 AllianceGenome:MGI:1194504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIR10; BIRK-1; Kir1.2; Kir4.1
Summary
Enables inward rectifier potassium channel activity. Involved in non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; ion transmembrane transport; and regulation of resting membrane potential. Located in astrocyte projection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; genitourinary system; spinal cord; stomach; and stria vascularis. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 42.3), frontal lobe adult (RPKM 31.1) and 3 other tissues See more
Orthologs
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Genomic context

See Kcnj10 in Genome Data Viewer
Location:
1 H3; 1 79.69 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172168777..172201652)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172341210..172374085)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11698 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 9 Neighboring gene STARR-positive B cell enhancer ABC_E3331 Neighboring gene STARR-positive B cell enhancer ABC_E4390 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class M Neighboring gene STARR-positive B cell enhancer mm9_chr1:174340789-174341090 Neighboring gene STARR-seq mESC enhancer starr_03060 Neighboring gene STARR-positive B cell enhancer ABC_E5854 Neighboring gene STARR-positive B cell enhancer ABC_E5855 Neighboring gene STARR-positive B cell enhancer ABC_E2020 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-glutamate import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to potassium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutamate reuptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within potassium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of resting membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 10
Names
inward rectifier K(+) channel Kir4.1
potassium channel, inwardly rectifying subfamily J member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039484.1NP_001034573.1  ATP-sensitive inward rectifier potassium channel 10

    See identical proteins and their annotated locations for NP_001034573.1

    Status: VALIDATED

    Source sequence(s)
    AC074311, AK044640, AK048864
    Consensus CDS
    CCDS15512.1
    UniProtKB/Swiss-Prot
    Q9JM63
    UniProtKB/TrEMBL
    B9EIV1, Q56VN0
    Related
    ENSMUSP00000054356.4, ENSMUST00000056136.4
    Conserved Domains (2) summary
    pfam01007
    Location:31172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179354
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172168777..172201652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496677.5XP_006496740.3  ATP-sensitive inward rectifier potassium channel 10 isoform X1

    UniProtKB/TrEMBL
    Q499F6
    Conserved Domains (2) summary
    pfam01007
    Location:129269
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:276451
    IRK_C; Inward rectifier potassium channel C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020269.3: Suppressed sequence

    Description
    NM_020269.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.