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Kcnh3 potassium voltage-gated channel, subfamily H (eag-related), member 3 [ Mus musculus (house mouse) ]

Gene ID: 16512, updated on 18-Sep-2024

Summary

Official Symbol
Kcnh3provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 3provided by MGI
Primary source
MGI:MGI:1341723
See related
Ensembl:ENSMUSG00000037579 AllianceGenome:MGI:1341723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Elk2; Melk2; Kv12.2; C030044P22Rik
Summary
The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. An increase in cognitive function was observed when this gene was knocked out, while deletion of the gene resulted in hippocampal hyperexcitability and epilepsy. [provided by RefSeq, Sep 2015]
Expression
Biased expression in frontal lobe adult (RPKM 30.6), cortex adult (RPKM 30.2) and 5 other tissues See more
Orthologs
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Genomic context

See Kcnh3 in Genome Data Viewer
Location:
15 F1; 15 56.08 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99122396..99140699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99224517..99242818)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183 Neighboring gene STARR-seq mESC enhancer starr_39699 Neighboring gene predicted gene, 46538 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene microspherule protein 1 Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (5)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 3
Names
ELK channel 2
ether a go-go like
ether-a-go-go-like potassium channel 2
voltage-gated potassium channel subunit Kv12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010601.4NP_034731.3  potassium voltage-gated channel subfamily H member 3

    See identical proteins and their annotated locations for NP_034731.3

    Status: REVIEWED

    Source sequence(s)
    AC161198
    Consensus CDS
    CCDS27817.1
    UniProtKB/Swiss-Prot
    B2RU85, E9QMZ8, Q6U1M1, Q9WVJ0
    Related
    ENSMUSP00000040548.4, ENSMUST00000041415.5
    Conserved Domains (3) summary
    TIGR03896
    Location:617712
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
    cl26073
    Location:227662
    Ank_2; Ankyrin repeats (3 copies)
    cl28304
    Location:41134
    PRK15347; two component system sensor kinase SsrA; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99122396..99140699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520483.5XP_006520546.1  potassium voltage-gated channel subfamily H member 3 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:233668
    PLN03192; Voltage-dependent potassium channel; Provisional
    TIGR03896
    Location:623718
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
    pfam13426
    Location:40135
    PAS_9; PAS domain
  2. XM_036159170.1XP_036015063.1  potassium voltage-gated channel subfamily H member 3 isoform X2

    Conserved Domains (3) summary
    PLN03192
    Location:173608
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:474
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:563658
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
  3. XM_036159171.1XP_036015064.1  potassium voltage-gated channel subfamily H member 3 isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:167602
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:474
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:557652
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
  4. XM_030248344.2XP_030104204.1  potassium voltage-gated channel subfamily H member 3 isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:167602
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:474
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:557652
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
  5. XM_006520484.4XP_006520547.1  potassium voltage-gated channel subfamily H member 3 isoform X2

    Conserved Domains (3) summary
    PLN03192
    Location:173608
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:474
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:563658
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
  6. XM_030248343.2XP_030104203.1  potassium voltage-gated channel subfamily H member 3 isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:167602
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:474
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:557652
    cyc_nuc_ocin; bacteriocin-type transport-associated protein