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Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 [ Mus musculus (house mouse) ]

Gene ID: 16510, updated on 18-Sep-2024

Summary

Official Symbol
Kcnh1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 1provided by MGI
Primary source
MGI:MGI:1341721
See related
Ensembl:ENSMUSG00000058248 AllianceGenome:MGI:1341721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAG1; M-eag; Kv10.1
Summary
Enables delayed rectifier potassium channel activity and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in potassium ion transmembrane transport; regulation of presynaptic cytosolic calcium ion concentration; and regulation of synaptic vesicle exocytosis. Is integral component of plasma membrane. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 6.6), frontal lobe adult (RPKM 5.5) and 9 other tissues See more
Orthologs
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Genomic context

See Kcnh1 in Genome Data Viewer
Location:
1 H6; 1 97.33 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191871759..192192467)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (192189144..192510159)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene REST corepressor 3 Neighboring gene predicted gene 10516 Neighboring gene predicted gene, 39745 Neighboring gene STARR-seq mESC enhancer starr_03453 Neighboring gene STARR-seq mESC enhancer starr_03454 Neighboring gene STARR-seq mESC enhancer starr_03455 Neighboring gene STARR-seq mESC enhancer starr_03457 Neighboring gene STARR-seq mESC enhancer starr_03458 Neighboring gene STARR-seq mESC enhancer starr_03459 Neighboring gene predicted gene, 31011 Neighboring gene hedgehog acyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E2599 Neighboring gene predicted gene, 22265

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124419, MGC124420

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables cyclic nucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in startle response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily H member 1
Names
EAG channel 1
ether a go-go
ether-a-go-go potassium channel 1
voltage-gated potassium channel subunit Kv10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038607.3NP_001033696.1  potassium voltage-gated channel subfamily H member 1 isoform 2

    See identical proteins and their annotated locations for NP_001033696.1

    Status: VALIDATED

    Source sequence(s)
    AC105325, AC109240, AC158791
    Consensus CDS
    CCDS35826.1
    UniProtKB/TrEMBL
    Q32MR7, Q3UHC9
    Related
    ENSMUSP00000106468.2, ENSMUST00000110844.3
    Conserved Domains (6) summary
    COG0664
    Location:548693
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:554664
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:39133
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:235483
    Ion_trans; Ion transport protein
    pfam07885
    Location:423477
    Ion_trans_2; Ion channel
    pfam13426
    Location:39135
    PAS_9; PAS domain
  2. NM_010600.4NP_034730.1  potassium voltage-gated channel subfamily H member 1 isoform 1

    See identical proteins and their annotated locations for NP_034730.1

    Status: VALIDATED

    Source sequence(s)
    AC105325, AC109240, AC158791
    Consensus CDS
    CCDS15627.1
    UniProtKB/Swiss-Prot
    Q32MR6, Q3USQ9, Q60603
    UniProtKB/TrEMBL
    A0A1L1M1J8
    Related
    ENSMUSP00000077563.6, ENSMUST00000078470.12
    Conserved Domains (6) summary
    COG0664
    Location:575720
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:581691
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:39133
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:235510
    Ion_trans; Ion transport protein
    pfam07885
    Location:450504
    Ion_trans_2; Ion channel
    pfam13426
    Location:39135
    PAS_9; PAS domain

RNA

  1. NR_185158.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC105325, AC109240, AC158791

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191871759..192192467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497229.2XP_006497292.1  potassium voltage-gated channel subfamily H member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q32MR6, Q3USQ9, Q60603
    Conserved Domains (3) summary
    PLN03192
    Location:160587
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK11753
    Location:548652
    PRK11753; cAMP-activated global transcriptional regulator CRP
    pfam13426
    Location:1475
    PAS_9; PAS domain
  2. XM_036162273.1XP_036018166.1  potassium voltage-gated channel subfamily H member 1 isoform X2

    UniProtKB/Swiss-Prot
    Q32MR6, Q3USQ9, Q60603
    Conserved Domains (3) summary
    smart00086
    Location:334
    PAC; Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
    PLN03192
    Location:119546
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK11753
    Location:507611
    PRK11753; cAMP-activated global transcriptional regulator CRP